合并小剂量喹硫平治疗躯体形式疼痛障碍的临床研究

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1、2014年1月中国民康医学Jan，2014第26卷半月刊第1期MedicalJournalofChinesePeople'sHealthVo1．26SemimonthlyNo．1【论著】合并小剂量喹硫平治疗躯体形式疼痛障碍的临床研究吴迎春，杨雅芬，赵业华。卢绍龙(辽宁省精神卫生中心，辽宁开原112300)【摘要】目的：探讨合并小剂量喹硫平对躯体形式疼痛障碍的疗效及安全性。方法：对81例躯体形式疼痛障碍的患者随机分成研究组(41例)和对照组(40例)，研究组给予西酞普兰合并小剂量喹硫平系统治疗，对照组给予西酞普兰

2、系统治疗，疗程均为6周。入组患者分别于治疗前、治疗后1，2，4，6周末采用汉密尔顿抑郁量表(HAMD)、疼痛量表(MOSPM)评定疗效，用治疗时出现的症状量表(TESS)在治疗后1，2，4，6周末评定不良反应。结果：与治疗前相比，研究组HAMD及MOSPM评分在第1周末即有显著性降低(P

3、痛障碍与西酞普兰系统治疗相比，疗效肯定。起效快，安全性高，依从性好。【关键词】喹硫平；西酞普兰；躯体形式疼痛障碍doi：10．3969／j．issn．1672-0369．2014．01．004中图分类号：R971．4；R441．1文献标识码：A文章编号：1672—0369(2014)01—0009—03ClinicalstudyofcitalopramcombinedwithlowdosequetiapineintreatmentofsomatoformpaindisordersWUYing-ehun，YANG

4、Ya-fen，ZHAOYe-hua，etal(MentalHealthofLiaoningProvince，Kaiyuan，Liaoning112300，China)【Abstract】Objective：Toexploreeficacyandsafetyofcitalopramcombinedwithlowdosequetiapineintreatmentofsomato．formpaindisorders．Methods：Eighty-onepatientswiththesomatoformpaindiso

5、rderswererandomlydividedintostudygroup(41ca—ses)andcontrolgroup(40cases)，whereinthecasesweretreatedwithcitalopramcombinedwithlowdosequetiapineandcitalopramfor6weeks，respectively．TheeficacywasevaluatedbyHamiltondepressivescale(HAMD)andmedicaloutcomesstudypain

6、meas—urement(MOSPM)beforeandweek1，2，4and6weeksafterthetreatment．Thesideeffectswereassessedbytreatmentemergentsymptomscale(TESS)1，2，4and6weeksafterthetreatment．Results：Afterthetreatment，thescoresofHAMDandMOSPMofstudygroupdecreasedsignificantly1weekafterthetre

7、atment(P<0．05)，whereasthoseofcontrolgroupdecreased2weeksafterthetreatment(P<0．05)．6weeksafterthetreatment，thewholecurativeeffectsofstudygroupwerebetterthanthoseofcontrolgroup(P<0．05)．TherewasnosignificantdifferenceinTESSscoresbetweenthetwogroups．Conclusions：

8、Comparedwithcitalopram，citalo—pramcombinedwithquetiapineinthetreatmentofsomatoformpaindisordersismoreeffectiveandhashighsafetyandgoodcompli—alice．【Keywords】Quetiapine；Citalopram；Somatoformpaindi