高血压病患者血清chemerin与胰岛素抵抗及炎症的关系.pdf

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1、塑堡茔±旦箜26卷第1期MedJWestChina，January2014，Vo1．26，No．1·37·高血压病患者血清chemerin与胰岛素抵抗及炎症的关系*彭清，卢建刚，王小洁。，陈梅。(泸州医学院附属医院1．心内科；2．内分泌科}3．血液内科，四川泸州646000)【摘要】目的研究高血压痛患者血清chemerin水平与胰岛素抵抗及炎症相关性。方法选择5O例无糖尿痛病史的高血压痛患者(高血压组)和4O例体检正常者(对照组)，收集一般临床资料，测量血压、腰围、臀围，测定空腹血糖，空腹胰岛素，hsCRP等生化指标，采用ELIS

2、A法测定两组血清chemerin水平，并用胰岛素抵抗指数(1RI)作为胰岛素敏感性评价指标。结果高血压家族史、腰围、血压、空腹胰岛素IRI、hsCRP及Chemerin在高血压组和对照组之间差异有统计学意5C(P

3、gistic多因素回归分析发现高血压家族史、IRI、hsCRP及Chemerin与高血压密切相关(P

4、insulinresistanceandinflammationinhypertensivepatientsPENGQing，LUJian-gang，WANGXiao-jie，etai(DepartmentofCardiology，TheA}{tliatedHospitalofLuzhouMedicalCollege，Luzhou646000，Sichuan，China)[Abstract]ObjectiveTostudytherelationshipofserumehemerinlevelwithinsulinresistanc

5、eandinflammationinhypertensivepatients．MethodsThebasicinformationwascollectedinfiftyhypertensivepatientswithoutdiabetichisto—ryandfortynorma1peopleascontro1．Bloodpressure，waistcircumferenceandhipcircumferenceweremeasured．Thenbloodsamplesweretakenfromthemformeasurement

6、ofbiochemiea1indicators．Fastingserumchemerinwastestedbyenzyme1inkedimmunosorbentassay(ELISA)．Insulinresistanceindex(IRI)wasappliedtoestimateinsulinresistance．ResultsUnivariateanalysisshowedthatsignificantdifferencewasfoundinfamilyhistoryofhypertension，waisteircum—fere

7、nce，bloodpressure，IRI。hsCRPandchemerinbetweenthehypertensivepatientsandthoseinnormalcontrolgroup(P

8、forageandgender，partialCorrelationa’nalysisshowedthattheehemerinlevelofthehypertensivepatientswaspositivelycorrelatedwithIRI