欢迎来到天天文库
浏览记录
ID:53572778
大小:324.17 KB
页数:4页
时间:2020-04-19
《非诺贝特与2种β-环糊精水溶性衍生物在水溶液中包合作用研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、CentralSouthPharmacy.April2013,Vo1.11No.4中南药学2013年4月第11卷第4期非诺贝特与2种环糊精水溶性衍生物在水溶液中包合作用研究谷福根,高源源一,吴春芝,韩洪波(1.内蒙古医科大学附属医院,呼和浩特010050;2.内蒙古医科大学药学院呼和浩特010110)摘要目的研究羟丙基环糊精(HP-fl—CD)及磺丁基醚环糊精(SBE-fl-CD)在水溶液中对非诺贝特(fenofibrate,FNB)的包合作用。方法分别采用紫外吸收光谱法、相溶解度法研究HP-fl-CD及SBE-fl-CD在水溶液中对FNB的包合作用、增溶作用及
2、包合过程中热力学参数的变化。结果FNB与2种fl-CD水溶性衍生物在水溶液中均存在明显的分子间相互作用。FNB的溶解度随着2种.CD水溶性衍生物浓度的增加而呈线性增加,相溶解度图呈AL.型。包合过程中的热力学参数变化包括吉布斯自由能变化(△G)、焓变(△)、熵变(△S)均为负值。结论FNB与HP-f1.CD及SBE-f1.CD在水溶液中均可自发形成1:1克分子比可溶性包合物,从而增加其溶解度。同时,包合过程均为焓驱动过程,且为放热反应(△日<0),熵减过程(△S<0)。适当降低温度将有利于包合过程的进行。关键词:非诺贝特;羟丙基.环糊精;磺丁基醚.环糊精;溶解度
3、;热力学参数中图分类号:R944.9文献标识码:A文章编号:1672—2981(2013)04—0258—04doi:10.7539~.issn.1672—2981.2013.04.006Complexationoffenofibratewith2water-solublep-coderivativesinaqueoussolutionGUFu.gen,GAOYuan—yuan1,2,WUChun.zhi,HANHong—bo(1.DepartmentofPharmacy,AfiliatedHospital,lnnerMongoliaMedicalUnivers
4、ity,Hohhot010050;2.SchoolofPharmacy,lnnerMongoliaMedicalUniversity,Hohhot010110)Abstract:0bjectiveToinvestigatethecomplexationoffenofibrate(FNB)with2Water.soluble.CDderivativesin.eludinghydroxypropyl-fl—cyclodextrin(HP一一CD)andsulfobutylether-fl—Cyclodextrin(SBE-fl—CD)inaqueoussolutio
5、n.MethodsTheintermolecularactionbetweenthehostandguestmolecules,thesolubilizingefectofeachCDderivativeonFNBinaqueoussolutionandthechangesofthermodynamicparametersinthecomplexationwerestudiedbvUVabsorp—tionspectra.andphasesolubilitymethod.ResultsSignificantinteractionbetweenthehostand
6、guestmoleculesinaqueoussolutionwasconfirmed.ThesolubilitiesofFNBinaqueoussolutionsincreasedlinearlywiththeincreasingconcentrationofeachCDderivative,showingatypicalAL—typephasesolubilitydiagram.Thevaluesof3thermodynamicparameters,name-lv△G.A日andASintheformationofeachinclusioncompleXwe
7、reallnegative.Conelusio11A1:lmolarratioinclusioncomplexofFNBwitheachCDderivativeformsspontaneouslyatallexperimentaltemperaturesandthusthesolubilityofFNBintheaqueoussolutionisobviouslyincreased.A11thecomplexationprocessesareenthalpicallydrivenandareexother-mic.Therefore,appropriatelyl
8、owtemperatur
此文档下载收益归作者所有