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1、文拉法辛和帕罗西汀治疗抑郁症临床效果观察［摘要］目的探讨文拉法辛缓释剂和帕罗西汀治疗抑郁症的效果。方法选择本院2012年6月〜2013年3月收治的抑郁症患者60例，随机分为A、B两组，其中A组给予文拉法辛缓释剂治疗，B组给予帕罗西汀治疗，两组均治疗2个月，采用汉密尔顿抑郁量表（HAMD）、临床疗效总体评价量表（CGI）评价治疗效果，观察两组治疗不良反应情况。结果两组治疗后HAMD、CGI量表评分均较治疗前降低（P0.05）；治疗1、4、8周时两组CGI评分差异均无统计学意义（P>0.05）；治疗后两组有效率比较，差异无统计学意
2、义（P>0.05）。两组治疗过程中均出现口干、便秘、恶心、心电图异常等不良反应，但组间差异无统计学意义，且不良反应经对症处理后均减轻或消失，未影响治疗。结论文拉法辛缓释剂和帕罗西汀治疗抑郁症的疗效无明显差异，安全性均较高，但文拉法辛起效时间较帕罗西汀短，值得应用。［关键词］抑郁症；文拉法辛；帕罗西汀；疗效；不良反应［中图分类号］R971+.43［文献标识码］A［文章编号］1674-4721（2013）11（b）-0069-02Theclinicalefficacyofvenlafaxineextendedreleaseform
3、ulationsandparoxetineintreatmentofdepressionDENGYUPharmacyDepartmentofBrainHospitalinHunanProvince,Changsha410007,China[Abstract]ObjectiveToinvestigateefficacyandsafetyofvenlafaxineextendedreleaseformulationsandparoxetineintreatmentofdepression.Methods60patientswith
4、depressionfromJune2012toMarch2013inourhospitalwererandomlydividedintotwogroups,patientsingroupAweregivenvenlafaxineextendedreleaseformulationstreatment，patientsingroupBweregivenparoxetinetreatment,theywerealltreatedfortwomonths,andthentheHamiltondepressionratingscal
5、e(HAMD),theoverallclinicalratingscale(CGI)wereusedtoevaluatethetherapeuticeffects,andadversereactionswereobserved・ResuItsAftertreatment,HAMD,CGIscorewerelowerthanthatbeforetreatment(P0・05)；After1,4,8weekstreatmentCGIscoresbetweentwogroupswerenotstatisticallysignific
6、ant(P>0.05)；andtreatmentefficiencyoftwogroupscompared,thedifferencewasnotsignificant（P〉0・05）・Duringthetreatment,mouthdry，constipation，nausea，abnormalelectrocardiograinandotheradversereactionswereallfoundintwogroups,butthedifferencewasnotsignificant,andtheadversereac
7、tionswerereducedordisappearedaftersymptomatictreatment,anddidnotaffectthetreatmerit.ConclusionVenlafaxineextendedreleaseformulationsandparoxetineinthetreatmentofdepressionhasnosignificantdifferenceinefficacy,andthesafetyishigh,buttheonsettimeofvenlafaxineisshort,soi
8、tisworthyofapplication.[Keywords]Depression；Venlafaxine；Paroxetine；Efficacy；Adversereaction抑郁症是一种常见的心境障碍，可由各种原因引起，以显著而持久的心境低落为主要临床特征，严重者可出
