羊膜移植联合低浓度丝裂霉素c治疗原发性青光眼比较观察

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1、第2l卷第7期航空航天医药2010年7月1141厶羊膜移植联合低浓度丝裂霉素，口疗原发性青光眼比较观察彭坤，陆丽红，杨培学(新乡医学院第一附属医院眼科，河南新乡4531oo)摘要目的：对比观察羊膜移植联合低浓度丝裂霉素C在治疗原发性青光眼中的临床效果。方法：对33例48眼原发性急性闲角型青光眼患者分为两组，联合组和单纯组，联合组采取低浓度丝裂霉素联合羊膜移植、小梁切除术治疗，单纯组用较高浓度丝裂霉素、小梁切除术，术后观察眼压、视力、滤过泡及并发症。结果：联合组视力提高较单纯组视力提高明显，且有显著性差异(P<005)；术后3个月随访时，单纯组眼压控制较联合组低，且差异有显著性(P

2、<0．05)；联合组功能性滤过泡(87．5％)较单纯组(70．83％)高，并发症较单纯组少。结论：羊膜移植联合低浓度丝裂霉素治疗原发性青光眼具有眼压控制满意，并发症少等优点。关键词羊膜移植；丝裂霉素；原发性青光眼doi：10．3969／j．issn．1005—9334．2010．07．027中图分类号：R775文献标识码：AAClinicalComparativeStudyofAmnioticMembraneTransplationCombinedMitomycinCAppliedinPrimaryGlaucomaPENGKun，LULi—hong，YANGPei—xue(Dep

3、artmentofOphthalmology，ThenAffiliatedHospitalofXinxiangMedicalCollege，Xinxiang453100，China)AbstractObjective：Tostudytheclinicaleffectoftrabeculectomycombinedwithamnioticmend~ranetransplationandmitomycinCinprimaryglaucoma．Methods：Thirty—threecasesf48eyes)withprimaryglaucomawererandomizedintotw

4、ogroups：thecombinedgroupunderwenttrabeculectomycombinedwithamnioticmembranetransplationandmito-mycin；thesinglegroupwithtraditionaltrabeculectomyandmitomycinC．Theintraocularpressuer(IOP)，visualacuity，filteringblebsweremeasuredandcomparedbetweenthetwogroupsafteroperation．Results：Thedecreaseofvi

5、sualacuitywasseenin10eyes(41．7％)ofthesinglegroup，whereasonly2eyes(8．7％)incombinedgroup，thediferencebe·tweenthetwogroupswassignificantly(P<0．05)．Intheearlystageofpostoperation，theIOPintwogroupshasnodifference，threemonthslater，thelOPinsinglegroupwaslowerthanthatofthecombinedgroup，thediferencewa

6、ssig-nificant(P<0．05)．Thepercentageoffunctioningblebsincombinedgroupwas87．5％，andthatinthesinglegroupwas70．83％．Complicationsinvolvingshallowanteriorchamber，blebleaking，persistanthypotony，nlaculal"edemawaslessincombinedgroupthanthatinsinglegroup．Conclusions：Amnioticmembranetransplationcombinedl

7、owdosemitomycinCcaneffectivelycontrollOPandmaintainthefunctionalbleb，andhaslesscomplications，itisworthyofapplicationinglau-comasurgicaloperation．KeywordsAmnioticmembranetransplation；MitomycinC；Primaryglaucoma丝裂霉素自应用到青光眼手术中以来，其抗纤维化和霉素治疗，效果比较报道