鼻腔给予丙酸睾丸酮对雌性大鼠旷场行为的影响

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1、河北医药2014年1月第36卷第1期HebeiMedicalJournal，2014．Vol36JanNo．15doi：10．3969／j．issn．1002-7386．2014．01．001·论著·鼻腔给予丙酸睾丸酮对雌性大鼠旷场行为的影响闫文升薛岩孙幸杨欢康洁康云霄张国梁【摘要】目的观察雌性大鼠长期鼻腔给予丙酸睾丸酮后的旷场行为变化，推测鼻腔给予丙酸睾丸酮对中枢神经系统的影响。方法通过旷场实验观察雌性大鼠鼻腔给予丙酸睾丸酮后静止闻嗅行为、探索行为、趋触性行为、运动行为和理毛行为的变化。结果Intaet-T组的静止状态闻噢次数比正常组增加了47％(P<0．05)。Intact-T组大鼠

2、鼻腔给予丙酸睾丸酮后climbing、rearing和sniffing行为次数比正常组分别减少了43％(P<0．05)、56％(P<0．05)和40％(P<0．05)。Intact—T组大鼠鼻腔给予丙酸睾丸酮后垂直运动、水平运动和总径长比正常组分别减少了46％、45％和42％(P均<0．05)。Intact—T组大鼠鼻腔给予丙酸睾丸酮后理毛潜伏期比正常组减少了84％(P

3、文献标识码】A【文章编号】1002—7386(2014)01—0005—03EfectsofintranasaladministrationoftestosteTonepropionateontheopenfieldbehaviorsoffemaleratsⅣWensheng’，XUEYan，SUNXing，eta1．’DepartmentofAnatomy，ShijiazhuangMedicalCollege，Sh~iazhuang050071，China【Abstract】ObjectiveToinvestigatetheeffectsoflong—termintranasaladm

4、inistrationoftestosteronepropionateonthecentralnervoussystembyanalyzingtheopenfieldbehaviorofrats．MethodsTheopenfieldtestwasusedtoanalyzefivetypesofbehavioralpatternsoffemaleratsincludingstaticsnifingbehavior，exploratorybehavior，thigmotaxisbehavior，motorbehaviorandgroomingbehavior．ResultsAfterint

5、ranasaladministrationoftestosteronepropionatethestaticsnifingnumberoftimesinintact-Tgroupwereincreasedby47％，ascomparedwiththoseinintactgroup(P<0．05)．Thenumberoftimesofclimbing，rearingandsnifingbehaviorinintactTgroupweredecreasedby43％，56％，40％，respectively，ascomparedwiththoseinintactgroup(P<0．05)．T

6、heverticalactivity，horizontalactivityandthetotalpathlengthinintactTgroupweredecreasedby46％，45％，42％，respectively，ascomparedwiththoseinintactgroup(P<0．05)．ThelatencytimeofgroominginintactTgroupwasdecreasedby84％，however，groomingeventsandthedurationofgroomingwereincreasedby48％，ascomparedwiththoseinin

7、tactgroup(P<0．05)．ConclusionThelong—termintranasaladministrationoftestosteronepropionatecanincreasestaticbehaviorsoffemalerats，however，whichcandecreasetheratsactivitybehaviorsinopenfieldtest．【Keywords】testosterone；intr