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1、Criticalillnesspolyneuropathyandmyopathy:asystematicreviewChunkuiZhou1,2,LiminWu1,3,FengmingNi4,WeiJi5,JiangWu1,HongliangZhang11DepartmentofNeurology,theFirstBethuneHospital,JilinUniversity,Changchun130021,JilinProvince,China2DepartmentofNeurology,theSecondPart,th
2、eFirstBethuneHospital,JilinUniversity,Changchun130021,JilinProvince,China3NeuroprotectionResearchLaboratory,MassachusettsGeneralHospital,HarvardMedicalSchool,Charlestown02129,MA,USA4DepartmentofRadiotherapy,OncologyCenter,theFirstBethuneHospital,JilinUniversity,Ch
3、angchun130021,JilinProvince,China5DepartmentofVascularSurgery,People’sHospitalofJilinProvince,Changchun130000,JilinProvince,China窗体顶端Abstract:Criticalillnesspolyneuropathyandcriticalillnessmyopathyarefrequentcomplicationsofsevereillnessthatinvolvesensorimotoraxons
4、andskeletalmuscles,respectively.Clinically,theymanifestaslimbandrespiratorymuscleweakness.Criticalillnesspolyneuropathy/myopathyinisolationorcombinationincreasesintensivecareunitmorbidityviatheinabilityordifficultyinweaningthesepatientsoffmechanicalventilation.Man
5、ypatientscontinuetosufferfromdecreasedexercisecapacityandcompromisedqualityoflifeformonthstoyearsaftertheacuteevent.Substantialprogresshasbeenmadelatelyintheunderstandingofthepathophysiologyofcriticalillnesspolyneuropathyandmyopathy.Clinicalandancillarytestresults
6、shouldbecarefullyinterpretedtodifferentiatecriticalillnesspolyneuropathy/myopathyfromsimilarweaknessesinthispatientpopulation.Thepresentreviewisaimedatprovidingthelatestknowledgeconcerningthepathophysiologyofcriticalillnesspolyneuropathy/myopathyalongwithrelevantc
7、linical,diagnostic,differentiating,andtreatmentinformationforthisdebilitatingneurologicaldisease.Keywords：nerveregeneration;neurodegenerativediseases;criticalillnesspolyneuropathy;criticalillnessmyopathy;intensivecareunit;sepsis;multipleorganfailure;Guillain-Barré
8、;syndrome;NSFCgrant;neuralregeneration;窗体底端Acceptancedate:2013-11-25 Citethisarticle:ChunkuiZhou,LiminWu,FengmingNi,WeiJi,JiangWu,HongliangZhang.Crit
