阿维A治疗寻常型银屑病的疗效及对血清VEGF、IL-6的影响.pdf

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1、718GuangxiMedwaZJoltrnaZ，Jun．2014，Vo1．36，No．6阿维A治疗寻常型银屑病的疗效及对血清VEGF、IL一6的影响▲肖敏贺琪陶娟(华中科技大学同济医学院附属协和医院皮肤科，武汉市430022，E-mail：xuhonglai1973@163．COrn)【摘要】目的观察阿维A治疗中、重度寻常型银屑病的临床疗效及其对血清血管内皮生长因子(VEGF)、白细胞介素_l5(IL-6)水平的影响。方法32例银屑病患者口服阿维A治疗，疗程8周，治疗前后采用银屑病皮损面积和严重程度指数评分标准(PASI)进行疗效

2、评定；采用酶联免疫吸附试验(ELISA)测定患者治疗前后血清VEGF和IL45水平并与18例健康对照组比较。结果32例中、重度寻常型银屑病患者治疗8周后有效率为87．50％；治疗后血清VEGF、IL-6水平明显低于治疗前(P

3、子；白介素_l5【中图分类号】R751．05【文献标识码】A【文章编号】0253—4304(2014)06—0718-04DoI：10．11675／j．issn．0253．4304．2014．06．07EfficacyofAcitretinonPatientswithPsoriasisVulgarisandItsE仃酏tonSerumVascularEndothelialGrowthFactor．Interleukin-6XIAOMin，HEQi，TAOJuan(DepartmentofDermatology，AffiliatedU

4、nionHospital，TongfiMedicalCollege，HuazhongUniversityofScienceandTechnology，Wuhan430022，China)【Abstract】ObjectiveTostudythetherapeuticefectofacitretinonmoderateorseverepsoriasisvulgarisandeffectofacitretinonserumlevelsofvascularendothelialgrowthfactor(~EGF)，interleukin(

5、IL)-6．MethodsThirty—twopatientswithpsoriasisvulgarisweretreatedwithoralacitretin，andthetreatmentlastedfor8weeks．TheeficacyoftreatmentwasevaluatedbyPsoriasisAreaandSeverityIndex(PASI)scores．ThelevelsofVEGFandILg5inserumofpatientsweredetectedbyenzyme—linkedimmunosorbenta

6、ssay(ELISA)，andwerecomparedwiththehealthycontrols(18cases)．ResultsTheeffectiveratewasupto87．50％in32casesofmoderateorseverepsoriasisvulgarisafter8-weektreatment．TheserumlevelsofVEGFandIL-6aftertreatmentweresignificantlylowerthanthosebeforetreatment(P<0．O1)．Theserumlevel

7、sofVEGFandIL-6correlatedwithPASIscorespositivelyinpsoriasispatients(P<0．01)．TheserumlevelsofVEGFandIL-6ofpsoriasispatientsweresignificantlyhigherthanthoseofcontrolgroupbeforeandaftertreatment(P<0．O1)．ConclusionAcitretinhasbetterefectonthetreatmentofmoderateorseverepsor

8、iasisvulgarisbyinhibitingtheserumlevelsofIL-6andVEGF．【Keywords】Psoriasis；Acitretin；Vascularendothelialgrowthfactor；In