欢迎来到天天文库
浏览记录
ID:53271134
大小:155.47 KB
页数:2页
时间:2020-04-17
《Nanog在肺癌中的表达及对吉西他滨联合顺铂化疗疗效的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、现代医药卫生2013年5月15日第29卷第9期JModMedHealth,May15,2013,Vo1.29,No.9·128卜·论著·Nanog在肺癌中的表达及对吉西他滨联合顺铂化疗疗效的影响骆梅青,卜庆,曹轶林,郑桂银,伍爱华,施朕善(桂林医学院附属医院肿瘤内科,广西桂林541001)【摘要】目的探讨中晚期(Ⅲ、Ⅳ期)肺癌患者Nanog的表达及对吉西他滨联合顺铂化疗疗效的影响。方法采用免疫组化法检测62例肺癌患者Nanog的表达情况。研究其表达情况对吉西他滨联合顺铂化疗疗效的影响。结果62例晚期肺癌患者中Nanog表达阳性3O例(
2、48.4%),吉西他滨联合顺铂化疗有效组32例患者中Nanog表达阳性9例(28.1%),阴性23例(71.9%);无效组30例患者中Nanog表达阳性21例(70.0%),阴性9例(30.O%)。无效组患者Nanog表达阳性率明显高于有效组(X2=10.872,P=0.001)。结论Nanog表达增强可导致肺癌患者对吉西他滨联合顺铂化疗不敏感,检测Nanog对临床制订肺癌个体化治疗方案有一定参考价值。【关键词】肺肿瘤;基因表达;治疗结果;Nanog;化疗doi:10.3969~.issn.1009—5519.2013.09.001文
3、献标识码:A文章编号:1009.5519(2013)09.1281-02ExpressionofNanoginlungcanceranditsinfluenceonchemotherapicefectofcisplatincombinedwitIlgemcitabineLuoMeiqing,BuQ,CaoYilin,ZhengGuiyin,WuAihua,ShiZhenshan(DepartmentofOntology,AfiliatedHospital,GuilinMedicalCollege,Guiling,Guangxi5410
4、01,China)【Abstract】ObjectiveToinvestigatethetheexpressionofNanoginadvancedlungcancer(stagenlandIV)anditsin—fluenceonthechemotherapeuticeffectofcisplatincombinedwithgemcitabine.MethodsTheNanogexpressionin62patientswithlungcancerwasdetectedbyimmunohistochemicalmethodtostu
5、dyitsinfluenceonthecurativeefectofcisplatincombinedwithgemcitabinechemotherapy.ResultsAmong62patientsofmiddle—latestagelungcancer,30cases(48.4%)werepositiveexpressionofNanog.Among32casesintheeffectivegroupofcisplatincombinedwithgemcitabinechemotherapy,9cases(28.1%)werep
6、ositiveexpressionofNanogand23cases(71.9%)werenegavieexpressionofNanog.Among30casesinthein·efectivegroup,21cases(70.0%)werepositiveexpressionofNanogand9cases(30.0%)werenegavieexpressionofNanog.ThepositiveexpressionofNanogintheineffectivegroupwassignificantlyhigherthantha
7、tintheefectivegroup(P=O.001).Conclu-sionTheincreasedNanogexpressionmaycausethenon—sensitivetothechemotherapyofcisplatincombinedwithgemcitabineinlungcance.DetectingtheNanogexpressionhascertainreferencevalueformakingtheindividualizedclinicaltreatmentschemeinlungcancerpati
8、ents.【Keywortt~]Lungneoplasms;Geneexpression;Treatmentoutcome;Nanog;Chemotherapy肺癌是全世界最常见的恶性肿瘤.在恶性肿瘤相关死亡原因期(Ⅲ一
此文档下载收益归作者所有