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时间:2017-12-08
《β1受体基因和药物代谢酶cyp2d6*10与高血压病基因导向治疗的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、心血管康复医学杂志2013年l2月第22卷第6期ChinJCardiovascRehabilMed,December2013,Vo1.22No.6629757—765.actiOnofantiarrhythmicpeptides[J].NaunynSchmiedebergs[2O]TchouGD,WirkaRC,VanWagonerDR,eta1.Lowpreva—ArchPharmacol,2010,381(3):221—234.lenceofconnexin-40genevariantsinatri
2、altissuesandbloodfrom[z33IravanianS,DudleySCJr.Therenin-angiotensin-aldosteroneatrialfibrillationsubjects口].BMCMedGenet,2012,13:102system(RAAS)andcardiacarrhythmias[J].HeartRhythm,—113.2008,5(6Supp1):S12一S17.[21]YiSL,ZhongJQ,ZhangJ,eta1.ZP123reducesenerg
3、yre—[24]ChenHJ,YaoL,ChenTG,eta1.Atorvastainpreventedquiredfordefibrillationbypreventingconnexin43remodelingdur—connexin43remodelinginhyperophiedleftventricularmyocardi—ingprolongedventriculafibrillationinswine口].TexHeartInstumofspontaneouslyhypertensiver
4、ats口].ChinMedJ,2007,J,2012,39(6):784—791.120(21):1902—1907.[22]DheinS,HagenA,JozwiakJ,etalImprovingcardiacgap(收稿日期:2013—05—24)junctioncommunicationasanewantiarrhythmicmechanism:thel3受体基因和药物代谢酶CYP2D6*10与高血压病基因导向治疗的相关性研究张峰,杨军,李莉。摘要:随着基因治疗学研究不断深入,高血压病治疗也开始由
5、传统给药模式转向基因导向治疗的新模式。由于原发性高血压病的发病与遗传易感基因多态性有关,且基因分布存在种族及个体差异,导致药物疗效亦存在个体差异。本文对p受体基因(p一AR)和药物代谢酶CYP2D6*10的遗传多态性在美托洛尔“基因导向型个体化”降压治疗中影响的研究进展作一综述。关键词:高血压;受体,肾上腺素能Bt;基因文章编号:1008—0074(2013)06—629—03中图分类号:R544.109文献标识码:ADoi:10.3969/j.issn.1OO8—0074.2013.06.28Rese
6、archprogressionforinfluenceofp1receptorgeneandCYP2D6*10enzymepolymorphismingene-orientedtreatmentofhypertension/ZHANGFeng,YANGJun,LILiCorrespondingauthor:LILi,E-mail:jmslili@sina.cornAbstract:Alongwithgenetherapyresearchcontinuesdeveloping,hypertensiontr
7、eatmentstartsturningintonewmodeofgene.orientedtreatmentfromtraditionaladministrationmode.Becauseoccurrenceofessentialhypertensionisrelatedtogeneticpredisposinggenepolymorphism,andgeneticdistributionvariesamongracesandindividuals,leadingtoindividualdiffer
8、enceofdrugtherapeuticeffect.Thepresentarticlemadeanoverviewaboutresearchpro。gressionforinfluenceofgeneticpolymorphismsofp1receptorgene(61一AR)andCYP2D6*10enzymein“gene—orientedindividualization”loweringbloodpressuretreatmen
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