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1、原发性高血压肾病患者血清C■反应蛋白和尿微量蛋白水平检测的临床意义[摘要]目的：探讨原发性高血压肾病患者血清C■反应蛋白(CRP)和尿微量蛋白水平的变化及临床意义。方法：应用免疫比浊法对86例原发性高血压患者(正常蛋白尿组27例、微量蛋白尿组29例、大量蛋白尿组30例)血清CRP和尿微量蛋白水平进行检测，并与38例健康受试者(正常对照纟R)进行对比分析。结果：微量蛋白尿组及大星蛋白尿组患者血清CRP水平[(5.18±0.59)、(9.87±1.02)mg/L)]、尿[gG[(20.02±1.98)、(36.17±4.01)mg/L]、Alb[(70.46±7.12)、(260.31±24.0
2、8)mg/L]、TRF[(4.48±0.51)、(5.61±0.58)mg/L)]、al-MG[(29.87±2.82)、(55.64±5.70)mg/L]、p2-MG[(2.57±0.31)、(5.28±0.62)mg/L]等各项微量蛋白指标水平显著高于正常对照组与正常蛋白尿组，差异均有统计学意义(均P<0.05)；高血压肾病患者尿屮白蛋白排汕•率(UAER)与血清CRP及备项尿IgG、Alb、TRF>al・MG、P2-MG等各项微量蛋白指标水平呈正相关(尸0.62、0.58、0.54、0.63、0.72、0.49,均P<0.05)o结论：检测原发性高血压肾病患者血清CRP和尿微量蛋白水平
3、对观察其病情变化具有重耍的临床价值。[关键词]原发性高血压肾病；血清CRP；尿微量蛋白[屮图分类号]R446[文献标识码]B[文章编号]1673-7210(2011)12(a)-101-02ClinicalsignificaneeofdetectionofserumCRPandurinemicroproteinlevelsinpatientswithprimaryhypertensionnephropathyXULiqiongDepartmentofClinicalLaboratory,thePeople'sHospitalofLijiangCity,YiinnanProvince,Liji
4、ang674100,China[Abstract]Objective:ToexploretheclinicalsignificanceofdetectionofserumCRPandurinemicroproteinlevelsinthepatientswithprimaryhypertensionnephropathy.Methods:SerumCRPandurinemicroproteinlevelsweredetectedwithimmunoturbidimetryin86patients(27casesofthenormalalbuminuriagroup,29casesofthem
5、icroalbuminuriagroupand30casesofthemacroalbuminuriagroup)withprimaryhypertensionnephropathy,andcomparedwiththoseof38healthysubjects(thecontrolgroup).Results:SerumCRP[(5.18±0.59),(9.87±1.02)mg/L)],urineIgG[(20.02±1.98),(36.17±4.01)mg/L],Alb[(70.46±7.12),(260.3l±24.08)mg/L],TRF[(4.48±0.51),(5.61±0.58
6、)mg/L)],al-MG[(29.87±2.82),(55.64±5.70)mg/L],p2-MG[(2.57±0.31),(5.28±0.62)mg/L]inthemicroalbuminuriagroupandlargenumberbuminuriagroupweresignificantlyhigherthanthoseinthecontrolgroupandthenormalalbuminuriagroup(allP<0.05).UAERwaspositivelycorrelatedwithserumCRPandurinemicroproteinlevelsofIgG,Alb,TR
7、f,al-MGandP2-MG(r=0.62,0.58,0.54,0.63,0.72,0.49respectively,allP<0.05).Conclusion:ThedetectionofserumCRPandurinemicroproteinareallsensitiveinobservingthechangeofdiseasesinpatientswithprimaryhypertensionneph
