低分子量肝素联合硫酸镁治疗早发型子痫前期的疗效观察.pdf

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1、ModDiagnTreat现代诊断与治疗2015Apr26(8)·1683．低分子量肝素联合硫酸镁治疗早发型子痫前期的疗效观察罗冰，谢芳(信宜市人民医院，广东信宜525300)ObservationoftheCurativeEfectofLowMolecularWeightHep-arinCombinedwithMagnesiumSulfateonEarly。。onsetPreeclampsiaLUOBing，XIEFang(XinYicityofGuangdongProvincePeopleHospital，XinYi525300China)Abstract：

2、ObjectiveToexplorethecurativeeffectoflowmolecularweightheparincombinedwithmagnesiumsulfateonearly—onsetpreeclampsia．Methods116patientswithearly—onsetpreeclampsi·ainourhospitalwereselectedanddividedintothetreatmentgroupandthecontrolgroupac-cordingtodifferenttreatmentmethods，with58pati

3、entsineachgroup．Thetreatmentgroupwastreatedwithlowmolecularweightheparincombinedwithmagnesiumsulfate，andthecontrolgroupwastreatedwithonlymagnesiumsulfate．Theindexesofrenalfunction，bloodcoagulationfunction，complications，bloodpressureandgravidityextensiondaysofbothgroupswereobservedbef

4、oreandafterthetreatment．ResultsTheindexesofbloodpressureandbloodcoagulationfunctionofbothgroupschangedaftertreatment．TheindexvaluesofserumD—dimer，2"4hurineprotein，indexofurineprotein／urinecreatinine，gravidityextensiondaysandtheincidenceofneonatalsevereas—phyxiaofthetreatmentgroupwere

5、significantlybetterthanthoseofthecontrolgroup，andtheresultswerestatisticallysignificant(P<0．05)．ThedifferencesinotherindexessuchasPT，FBG，AP1[TI’andtheincidenceofcomplicationswerenotstatisticallysignificant>0．05)．ConclusionsLowmolecularweightheparincombinedwithmagnesiumsulfatehasgoode

6、ffectintreatingearly—onsetpreeclampsia，andcaneffectivelyimprovethekidneyfunctionandhighbloodcoagulationofpatients．Ithasdistinctclinicalcurativeeffectandthusisworthclinicalpromotion．Keywords：Preeclampsia；Lowmolecularweightheparin；IⅥagnesiumsulfate；Clinicaleffect摘要：目的探讨早发型子痫前期实施低分子量肝素联

7、合硫酸镁治疗的临床效果方法入选符合标准的早发型子痫前期患者116例，按治疗方式的不同分为治疗组和对照组，每组58例。治疗组给予低分子量肝素联合硫酸镁治疗，对照组给予常规硫酸镁治疗，观察两组治疗前后肾功能、凝血功能、并发症、血压及妊娠延长天数等各项指标。结果两组治疗后，血压和凝血功能各项指标均有变化，但治疗组血清D一二聚体指标值显著优于对照组。治疗组24h尿蛋白、尿蛋白／尿肌酐指标、妊娠天数、新生儿重度窒息发生率等显著优于对照组，具有统计学差异(氏O．05)；而Pr、FBG、AP丌等其他指标、并发症发生率等相比较，差异无统计学意义(尸>0．05)。结论低分子量肝素

8、联合硫酸镁治疗早发型子痫