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1、PathologyInternational1994;44:194199OriginalArticleSelectiveirondepositioninpancreaticisletBcellsoftransfusionaliron-overloadedautopsycasesJian-PingLu‘andKeikiHayashi’’DeparfmentofPathology,ShanghaiMedicalUniversity,Shanghai,Chinaand2DepartmentofPathology,OkayamaUniversity
2、,MedicalSchool,Okayama,JapanPancreaticisletsof36autopsycaseswithtransfusionaliron-overloadthatmimicshemochromatosisconfirmedthisoverloadwereexamined.lmmunohistochemicalandhisto-the~ry.~-~Surchargedironcaninducetissueinjurythroughchemicalstainingswereusedtoclarifytherelatio
3、nshipthegenerationoffreeradicals.6-BOntheotherhand,largebetweenbloodtransfusionandirondepositionintheislet.amountsofbloodtransfusionsinhereditaryhemopoieticDiseaseofthelyrnphohernopoieticsystem(leukemia,lyrn-systemdisorders,forexample,thalassemia,canresultinphorna,aplastic
4、anemia)orliver(carcinomaand/orcirrho-sis)accountedfor86.1%ofthepatients’maindiagnosis.transfusionaliron-overload.Iron-overloadduetobloodtrans-Sixteenofthemhadslighthernosiderindeposition(Groupl),fusionforotherdiseaseswithirondepositioninthepan-twentycaseshadseverehemosider
5、indeposition(Group2).creaticisletisconsideredrare.9,10AlthoughthereisglucoseAnothertencaseswereusedascontrols(Group3).TheintoleranceandreducedinsulinoutputinthepatientwithcaseshadasimilaragedistributiontoGroup1and2,withtransfusionaliron-overload,”l2noreportshavedealtwithne
6、itherbloodtransfusionnorhemosiderindeposition.Theimmunohistochemicalfindingsofthepancreaticislet.Autopsyvolumeofbloodtransfusionwas6.123.6,17.5t12.2Lforcaseswithtransfusionaliron-overloadwererequiredtoGroups1and2,respectively.Theplasmaglucosewasexaminethedistributionofhemo
7、siderinindifferentendocrine137.8254.4and170.6t108.4rng/dL,respectively.FourcasesinGroup1and14casesinGroup2hadglycosuria.cellsofthepancreaticislet.TherelationshipbetweenbloodThenumberofisletcellswithhernosiderinincreasedwithtransfusion,hemosiderindeposition,hyperglycemiaand
8、dia-theenlargementoftransfusionvolume(f=0.664,Pc::0.001).betesmellitusinthepatientswasals
