青壮年冠心病合并焦虑抑郁症的临床研究.pdf

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1、临床研究2011年1月第18卷第2期青壮年冠心病合并焦虑抑郁症的临床研究刘辉．岳兵。申艳芳(1．新乡医学院第一附属医院心血管内二科，河南卫辉453100；2．河南省鹤壁市六矿医院，河南鹤壁458000)【摘要】目的：探讨青壮年冠心病合并焦虑抑郁症的发病及治疗。方法：将272例青壮年冠心病患者采用Zung氏焦虑自评量表(SAS)及抑郁自评量表(SDS)评定焦虑抑郁情绪，检出合并焦虑抑郁症者72例，将其随机分为对照组和治疗组，前者给予常规治疗，后者在常规治疗同时加用抗抑郁药物氟西汀胶囊。观察8周。于治疗前及治疗第8周末

2、进行对比分析。结果：治疗组在治疗8周末SAS及SDS评分较治疗前及对照组均显著下降fP<0．05)，心绞痛、心律失常、心肌梗死及心源性猝死发生率明显降低(P<0．05)。结论：青壮年冠心病合并焦虑抑郁症患者同时加用抗焦虑、抗抑郁药物，其疗效显著优于常规治疗。f关键词】青壮年；冠心病；氟西汀胶囊；焦虑；抑郁[中图分类号]R541．4[文献标识码】A[文章编号】1674～4721(2011)O1(b)一034—02Clinicalstudyofonyoungadultsofcoronaryheartdiseaseacc

3、ompaniedwithdepressionandanxietyLIUHui，YUEBing,SHENYahfang(1．DepartmenttwoofCardiovascular，theFirstAffiliatedHospitalofXinxiangMedicalUniversity，HenanProvince，Weihui453100，China；2．TheSixthCoalHospitalofHebi，HenanProvince，Hebi458000，China)【Abstract】Objective：To

4、exploretheincidenceandtreatmentofyoungadultsofcoronaryheartdiseaseaccompaniedwithdepressionandanxiety．Methods：272youngadultscoronaryheaadiseasewereenrolledinthisstudy．72caseswerefoundedaccompaniedwithdepressionandanxietybytheZungSelf-RatingAnxietyScalefSAS)and

5、theZungSelf-RatingDepressionScale(SDS)．TheywererandomlydividedintoresearchgroupreceivingFluoxetineHydrochlorldeCapsulesplusroutinetreatmentandcontrolgroupdoingroutinetreatmentfor8weeks．Beforetreatmentandattheandofthe8weekstreatment，comparisonsandanalysesconduc

6、ted．Results：Attheendoftheeighthweek，theSASandSDSscoresignificantlyloweredcomparedwithpretreatmentintheresearchgroup(尸l<0．05)andcomparedwiththecontrolgroupP<0．05)．Attheendoftheeighthweek，theratesofangina，arrhythmia，myocardialinfarction，suddencardiacintheresearc

7、hgroupweresignificantlylowerthanthatinthecontrolgroup(P<0．05)．Conclusion：TheapplicationofFluoxetineHydmehlorldeCap—sulesplusroutinetreatmentinthetreatmentofanxiety—depressi0npatientsisbetterthantheroutinetreatment．【Keywords】Youngadults；Coronaryheartdisease；Flu

8、oxetineHydrochlorldeCapsules；Anxiety；Depression近年来，随着物质生活水平及临床检查技术水平的提绪，检出合并焦虑抑郁症者72例。人组标准：①冠心病诊断高，青壮年冠心病有增长趋势，由于社会、家庭等原因，青壮符合国际心脏病学会及世界卫生组织临床诊断标准；②排除年冠心病患者往往伴有情感障碍，尤其是焦虑、抑郁。相关文明显智