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1、368ISSN1007-8738细胞与分子免疫学杂志(ChinJCellMolImmunol)2010,26(4)·论著·文章编号:1007-8738(2010)04-0368-04JAK/STAT信号通路与肝细胞性肝癌的肿瘤进展和预后的相关性研究张斌,钟德玝3,王群伟,苗雄鹰,戴卫东,刘春,潘凯华(中南大学湘雅二医院普外科,湖南长沙410011)StudyoncorrelationofJAK/STAT[摘要]目的:探讨JAK/STAT信号通路在肝细胞性肝癌组织中的表达及其与预后的关系。方法:选取196例肝细胞性signalpathwaywithprogressi
2、onand肝癌组织标本,以正常肝脏组织标本20例作为对照,应用prognosisinhepatocellularcarcinomaSABC免疫组化方法检测JAK21蛋白和STAT23蛋白的表达,分析二者与肝细胞性肝癌的病理分级、临床分期及预后的关3ZHANGBin,ZHONGDe2wu,WANGQun2wei,MIAO系。结果:JAK21蛋白和STAT23蛋白在肝细胞性肝癌组织中Xiong2ying,DAIWei2dong,LIUChun,PANKai2hua的阳性表达率均高于正常肝脏组织(P=0.02,0.01);肝细胞DepartmentofGeneralSu
3、rgery,SecondXiangyaHospital,Central性肝癌中JAK21蛋白和STAT23蛋白的表达与患者性别、年SouthUniversity,Changsha410011,China龄、肿瘤大小、有无肝硬化均无显著相关;包膜不完整(P=0.01,0.008)、出现门静脉癌栓(P=0.02)、分化未成熟(P=[Abstract]AIM:ToinvestigatetheexpressionofJAK/0.01,0.009)、临床III～IV期(P=0.02,0.008)的肝细胞性STATsignalpathwayinhumanhepatocellu
4、larcarcinoma,肝癌组织中JAK21蛋白和STAT23蛋白的表达明显高于有完andtoevaluateitsclinicalsignificanceintheprogression整包膜、未出现门静脉癌栓、分化较成熟及临床I～II期的组andprognosisinhepatocellularcarcinoma.METHODS:196patientswithhepatocellularcarcinomawereexaminedfor织。Cox比例风险回归模型分析表明JAK21蛋白和STAT23蛋theexpressionofJAK21proteinandS
5、TAT23proteinby白均为影响肝细胞性肝癌预后的危险因素。结论:JAK/STATSABCimmunohistochemistry.RESULTS:Thepositiveex2信号通路的过度活化在肝细胞性肝癌的发生和发展过程中起pressionratesofJAK21proteinandSTAT23proteininpa2重要作用,可以作为评价肝细胞性肝癌恶性程度及预后的重tientswithhepatocellularcarcinomaweresignificantlyhigher要生物学指标。thanthosein20casesofnormalliver
6、tissue(P=0.02and[关键词]JAK/STAT信号通路;JAK21蛋白;STAT23蛋白;0.01,respectively).Therewasnosignificantrelationbe2预后;肝细胞性肝癌tweenthepositiveexpressionratesofJAK21proteinand[中图分类号]R392.11[文献标识码]BSTAT23proteinandpatients’sex,age,tumorsize,andcirrhosisofthehepatocellularcarcinomatissues(allP>肝细胞性肝癌(h
7、epatocellularcarcinoma)是我国0.05).TheJAK21proteinandSTAT23proteinwereex2pressedmorefrequentlyinhepatocellularcarcinomatissues发病率最高的恶性肿瘤之一,其恶性高,预后差,严withincompletecapsule(P=0.01and0.008,respective2重威胁人类的健康和生命。绝大多数肝细胞性肝癌,ly),venoustumoremboli(bothP=0.02),poorlydifferenti2都以手术切除为首选的外科综合治疗进
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