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1、帕罗西汀治疗癫痫伴发抑郁的疗效和安全性【摘要】目的:探讨分析帕罗西汀治疗癫痫伴发抑郁的疗效以及安全性。方法:采取回顾性分析法,收集2010年3月-2014年4月本中心诊治的120例癫痫伴发抑郁患者的临床资料,全部患者均应用帕罗西汀治疗,服用剂量为10〜30mg,平均剂量为(25.8土12.4)mg,观察120例患者治疗3个月后的癫痫发作频率、抑郁症状变化和副作用变化,并对治疗前后各指标进行比较分析。结果:经治疗后,110例患者抑郁症状有所好转,汉密尔顿抑郁量表评分明显下降,治疗前后比较差异有统计学意义(P0.05)。常见副作用为头晕,多发生于治疗后1个月内,经对症处理后均有所改
2、善。结论:经本次研究结果的分析可知,应用帕罗西汀治疗癫痫伴发抑郁,安全且有效,可有效改善患者抑郁症状,减少癫痫发作的次数,不良反应少且轻,可获得显著且良好的效果,值得在临床中应用以及推广。【关键词】癫痫;抑郁;帕罗西汀EfficacyandSafetyofParoxetineintheTreatmentofEpilepsyAssociatedwithDepression/XIELing-yin.//MedicalInnovationofChina,2015,12(23):141-143【Abstract】Objective:Toinvestigateandanalyzethee
3、fficacyandsafetyofParoxetineinthetreatmentofepilepsyassociatedwithdepression.Method:Accordingtoretrospectiveanalysismethod,theclinicaldataof120epilepticpatientswithdepressioninourcenterfromMarch2010toApril2014werecollected,al1patientsweregivenParoxetinetherapy,thedosewas10-30mg,theaveragedos
4、ewas(25.8+12.4)mg,theseizurefrequency,changesofdepressivesymptomsandsideeffectsin120patientsafter3monthsoftreatmentwereobserved,andtheeachindexesbeforeandaftertreatment,wereanalyzed.Result:Aftertreatment,thesymptomsofdepressionin110patientshadimproved,HamiltonDepressionScalescoredecreasedsig
5、nificanlly,beforeandaftertreatmenlcomparison,thediffereneewasstatisticallysignificant(卩0.05).Thecommonsideeffectisdizziness,occurredwithin1monthaftertreatment.,allofthemaftersymptomatictreatmenthadimproved.Conclusion:ThroughanalysisoftheresultsofthisstudyshowthatParoxetineinthetreatmentofepi
6、lepsyassociatedwithdepression,issafeandeffective,andcanimprovedepressivesymptomsofpa/tients,reducethefrequencyofepilepticseizures,fewersideeffectsandlight,obviousandgoodresultscanbeobtained,isworthyofclinicalapplicationandpromotion・[Keywords]Epilepsy;Depression;ParoxetineFirst-author'saddres
7、s:ThePeople'sHospitalofQingyuanCity,Qingyuan511515,Chinadoi:10.3969/j.issn.1674-4985.2015.23.049癫痫属于一种慢性反复发作性短暂脑功能失调综合征,其特征主要为因脑神经元界常放电造成的反复癫痫发作,在神经系统疾病中癫痫作为常见疾病,其发病率仅低于脑卒中,其发病率和年龄相关[1-2]o据调査资料显示,大约有40%〜60%左右的癫痫患者合并有抑郁症状[3],抑郁不仅容易使癫痫患者生活质量受到影响和干扰,同