欢迎来到天天文库
浏览记录
ID:5281534
大小:237.49 KB
页数:3页
时间:2017-12-07
《三维适形放疗联合唑来膦酸治疗转移性骨肿瘤的临床探讨》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、322塞旦垂生医堂生旦第24卷第4期PractGefiatr,August2010,Vo1.24。N0.4-_-_维适形放疗联合唑来膦酸治疗转移性骨肿瘤的临床探讨张汀荣许展赵韬顾小伟林青风【摘要】目的观察三维适形放疗联合唑来膦酸治疗转移性骨肿瘤的疗效和不良反应。方法58例老年转移性骨肿瘤患者,其中35例用三维适形放疗联合唑来膦酸治疗方案(联合组),将唑来膦酸4mg加入0.9%氯化钠注射液100ml中静脉滴注,滴注时间不少于15rain,每3~4周1次,共4次。骨转移灶局部给予三维适形放疗,共行4000Cgy,4周内分20次完成。
2、另外23例患者单纯使用唑来膦酸治疗(单药组)。比较治疗前后2组患者的疼痛缓解率、生活质量提高率以及治疗过程中的不良反应。结果经三维适形放疗联合唑来膦酸治疗后,联合组完全缓解(CR)17例(48.6%),部分缓解(PR)16例(45.7%),轻度缓解(MR)2例(5.7%),有效率(CR+PR)达94.3%,高于单药组的73.9%(P<0.05)。联合组患者生活质量明显改善,有效率达77.1%,也明显高于单药组的56.5%(P<0.05)。2种治疗方案对患者的不良反应除放疗引起的白细胞减少外,无明显差异。结论三维适形放疗联合唑来膦
3、酸相比较单独应用唑来膦酸治疗可明显缓解转移性骨肿瘤引起的疼痛,减少并发症的发生,提高患者的生活质量。【关键词】转移性骨肿瘤;三维适形放疗;唑来膦酸[中图分类号]R738.1[文献标识码]Adoi:10.3969/j.issn.1003-9198.2010.04.021ClinicalstudyofthreedimensionalconformalradiationtherapycombinedwithzoledronicacidforbonemetastasesofmalignanttumorZHANGTing—rong,XUC
4、hen,ZHAOTao,GUXiao—wei,LINQing-feng.DepartmentofOncology,JiangyinHospitalAffiliatedtoSoutheastUniversity,Jiangyin214400,China【Abstract】ObjectiveToevaluatetheeffectofthreedimensionalconformalradiationtherapy(3D—CRT)combinedwithzoledronieacidfortreatingbonemetastasesof
5、malignanttumor.MethodsZoledronicacid(4mg)withphysiologi—calsaline(100m1)wereinjectedonceeverythreetofourweeksforthreetimesin35elderlypatientswithbonemetasta—ses.DTradiometer(4000Cgyin4weeks)wasusedonthebonemetastaseszoneaccordingtothereportsofMRI.Twenty-threecasestre
6、atedonlywithzoledronicacidwerechosenascontro1.Remissionrateofpain,thequalitiesoflifeandthesideeffectswereevaluatedafterandbeforetreatmentrespectively.ResultsThetotaleffectiveratewas94.3%inthepatientsreceivingradiotherapycombinedwithzoledronicacid,withsignificantdiffe
7、rencecomparedtopatientsreceivingthesimpletreatmentofzoledronicacid.Thequalitiesoflifeinthecombinedgroupwereimprovedhigherthanthoseinthezole—dronicacidgroup.Thesideeffectswerereducedleucocytesinducedbyradiotherapy,whichcouldberevemedbysymptom—atictherapy.Conclusions3D
8、—CRTcombinedwithzoledronieacidcanrelievethepainandreducethecomplicationsofbonemetastases,whichismoreeffectivethansimpletreatmentofz
此文档下载收益归作者所有