间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局的影响.doc

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1、间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局的影响摘要目的：探讨间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局的影响。方法:选取2012年9月一2014年12月期间我院确诊治疗的先兆流产患者120例，依据随机分配原则分为黄体酮组和三酚酮组各60例，黄体酮组患者给予20mg黄体酮治疗，三酚酮组患者在此基础上给予40mg间苯三酚治疗，釆用新生儿阿氏评分法（Apgar）评估新生儿窒息情况，采用酶联免疫吸附法检测血清孕酮水平，随访至分娩，统计分析所有患者的疗效、治疗前、治疗后1、2、

2、3个月血清孕酮水平、不良反应及分娩结局情况。结果：三酚酮组患者治疗有效率明显高于黄体酮组（P0.05）,但所有患者治疗后孕酮水平均明显高于治疗前（P0.05）。结论：间苯三酚联合黄体酮治疗可有效提高先兆流产患者的疗效，改善患者血清孕酮水平，对分娩结局无不良影响，且具有良好的安全性。关键词间苯三酚黄体酮先兆流产分娩结局中图分类号:R714.21；R975.7文献标识码：A文章编号：1006-1533(2016)23-0028-04Effectsofphloroglucinolcombinedwithpr

3、ogesteronetreatmentonserumprogesteronelevelsandbirthoutcomesofpatientswiththreatenedabortion*XIAOYinghua(DepartmentofGynecologyandObstetrics,TraditionalChineseMedicineofJinggangshanCity,Jinggangshan343600,China)ABSTRACTObjective：Todiscusstheeffectsofphl

4、oroglucinolcombinedwithprogesteronetherapyonserumprogesteronelevelsandbirthoutcomesofpatientswiththreatenedabortion.Methods：Onehundredandtwentypatientswiththreatenedabortion,whoweretreatedinourhospitalfromSeptember,2012toDecember,2014,wereselectedandran

5、domlydividedintoaprogesteronegroup(treatedwithonlyprogesterone)andatriketophenonegroup(treatedwithprogesteroneplusphloroglucinol)with60caseseach.NeonataIasphyxiawasassessedbyneonataIApgarscoringmethodandserumprogesteronelevelsweredeterminedbyenzyme-link

6、edimmunosorbentandfollow-upwasperformedtillthedelivery・Thecurativeeffects,serumprogesteronelevelsbeforetreatmentandthefirsttothirdmonthsaftertreatment,adversereactionsandbirthoutcomeswerestatisticallyanalyzed.Results：Thetreatmentefficiencywasobviouslyhi

7、gherinthetriketophenonegroupthanintheprogesteronegroup(P0.05)，however,theywerehigherinallthepatientscomparedwithbeforetreatment(P0.05)・Conclusion：Phloroglucinolcombinedwithprogesteronetherapycaneffectivelyimprovethetreatmentefficacyandserumprogesteronel

8、evelsofpatientswiththreatenedabortionwithoutadverseeffectsonchildbirthoutcomebutwithgoodsafety.本研究通过给予患者间苯三酚联合黄体酮治疗,■IR发现三酚酮组治疗有效率明显高于黄体酮组，二者治疗后1、2、3个月血清孕酮水平基本相同，但治疗后孕酮水平明显高于治疗前，表明该联合治疗可有效提高患者的疗效，改善患者血清孕酮水平。本研究结果提示，在治疗过程中，通过20mg黄