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1、注射型卩坐来麟酸盐治疗绝经兀骨质疏松症临床观察［摘要］目的探讨
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3、坐来麟酸注射液治疗绝经示骨质疏松症的临床疗效，评价其安全性。方法将绝经后骨质疏松症患者70例随机分成治疗组和对照组，各35例，两组在年龄、绝经年限等方面比较差异均无统计学意义(P>0.05)。治疗组给予啤来麟酸注射液(密間达)5mg/100mL静滴1次，同时口服钙尔奇片-。对照组仅给予口服钙尔奇片，两组受试者均连续服药10个月。观察骨痛、骨密度变化及安全性指标。结果治疗示治疗组骨痛症状明显缓解,两组总有效率比较并异有统计学意义(P<0.05)；骨密度检测治疗组增加与对照组比较差
4、异有统计学意义(P<0.05)；治疗期间治疗组无新发骨折。结论I!坐来麟酸注射液对绝经后骨质疏松症患者具有缓解骨痛、增加骨密度、提高生活质量、减少骨折发生的作用，是一种有效、安全的药物。［关键词］哇來憐酸；骨质疏松；绝经后；骨密度［中图分类号］R681［文献标识码］A［文章编号］1673-7210(2012)01(c)-0073-02ClinicalobservationofZoledronicAcidSaJtInjectioninthetreatmentofpostmenopausalosteoporosisSONGYanyunlXINJi
5、an21.ShandongAthleteRehabilitationCenter,ShandongProvince,Ji'nan250102,China;2.TheAffiliatedHospitalofShandongUniversityofTraditiontilChineseMedicine,ShandongProvince,Ji'nan250011,China［Abstract］ObjectiveToexploretheclinicalefficacyofZoledronicAcidInjectioninthetreatmentofp
6、ostmenopausalosteoporosisandtoassessitssafety.Methods70patientswithpostmenopausalosteoporosiswererandomlydividedintotreatmentgroupandcontrolgroup,with35casesineachgroupandnosignificantdifferencesinage,menopauseandsoon(P>0.05).Forthetreatmentgroup,5mg/100mLofZoledronicAcidIn
7、jection(Adasta)wasinfusedoncewhileCaltratewastakenora11y・Forthecontrolgroup,onlyCaltratewastakenorally・Subjectsofthetwogroupstookmedicincfor10consecutivemonths・Thenbonepain,bonemineraldensity(BMD)varianeeandsafetyindicatorswereobserved・ResultsAftertreatment,thebonepainofthe
8、treatmentgroupwasmitigatedgreatly,thediffereneeofthetotaleffectiveratebetweenthetwogroupswassignifiednt(P<0.05);theBMDincreasewassignifiedntcomparedwiththatofthecontrolgroup(P<0・05);duringthetreatment,nonewfracturesoccurredinthetreatmentgroup・Cone1usionZoledronicAcidInjecti
9、oncaneasethebonepainofpostmenopausalosteoporosis,improvelifequa!ity,increaseBMDandreducetheoccurrencesoffractures;itisaneffectiveandsafedrug>［Keywords］ZoledronicAcid;Osteoporosis;Postmenopausal;Bonemineraldensity原发性骨质疏松症是以骨量减少，骨小梁变细、数量减少，皮质骨多孔、变薄为特征，导致骨的脆性增加和易于发生骨折为特征的全身性骨病
10、，包括绝经后骨质疏松症和老年性骨质疏松症。研究发现，双麟酸盐类药物可明显增加绝经后骨质疏松症患者的骨密度，降低骨折发生率。2009年10月〜2010年11月我院对3
