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1、老年睡眠呼吸暂停患者动脉硬化危险因素的探讨目的探讨老年阻塞型睡眠呼吸暂停低通气综合征(Obstructivesleepapneahypopneasyndrome,OSAS)患者超敏C反应蛋白(HighsensitivityCreactiveprotein,Hs~CRP)、同型半胱氨酸(Homocysteine,IIcy)>TG、TC、LDL-C水平变化及其与颈动脉内膜中层厚度(Carotidarteryintima-mediathickness,CIMT)>斑块的相关性。方法选取老年高血压、2型糖尿病患者129例，根据有无OSAS
2、分为OSAS组(60例)和非OSAS组(69例)，选取健康老年人30例作为正常对照组，所有入选者均记录年龄、性别、身高和体重，检测Hs-CRP、Hey、TG、TC、LDL-C和颈动脉内膜中层厚度(CIMT),对比OSAS组和非OSAS组Hs-CRP、Hey、TG、TC、LDL-C和CIMT的差异,OSAS组和非OSAS组分别与止常对照组比较各指标差界。分析CIMT和颈部斑块分别与Hs-CRP、Hey、TG、TC、LDL-C.年龄及BMI的相关性。结果(1)OSAS组与正常对照组比较,Hs-CRP、Hey、CIMT、TG、TC、LD
3、L-C均高于正常对照组，差异有统计学意义(P0.05)。非OSAS组与正常对照组比较,Hs-CRP、Hey、CIMT、TG、TC、LDL-C均高于止常对照组，差异有统计学意义(P0.05)oOSAS组与非OSAS组比较，Hs-CRP、Hey、CIMT及斑块积分均高于非OSAS组，差异有统计学意义(PO.05)o(2)相关分析显示，OSAS组CIMT与年龄、BMI、TG、TC、LDL-C、Hs-CRP、Hey均正相关。OSAS组斑块积分与年龄、BMRTG、TC、LDL-C、Hs-CRP、Hey均正相关。(3)多元线性回归分析显示，O
4、SAS组年龄、BMI、LDL-C、Hs-CRP、Hey均是CIMT的影响因素(均卩〈0.05)。OSAS组年龄、BMI.LDL-C、Hs-CRP、Hey均是颈动脉斑块的影响因素(均P<0.05)o结论(1)OSAS患者Hs-CRP、Hey、CIMT及颈动脉斑块水平高于正常对照组，高于非OSAS组，是动脉粥样硬化(Atherosclerosis,AS)的易患人群，OSAS是老年AS的危险因素。(2)CIMT与年龄、BMKLDL-C、Hs-CRP、Iley是老年OSAS患者AS的危险因素。(3)Hs-CRP、Hey水平变化可能对老年O
5、SAS患者AS的预防有重要作用。关键词阻塞型睡眠呼吸暂停低通气综合征，Hs-CRP,Hey,CIMTObjectiveToinvestigatetheHs~CRP(HighsensitivityCreactiveprotein),Iley(Homocysteine),TG,TC,LDL-ClevelsinelderlyOSAS(ObstructivesIeepapneahypopneasyndrome)patients,andthecorrelationbetweenthemandCIMT(Carotidarteryintima-
6、mediathickness),Carotidarteryplaque.Methods129elderlyhypertensionandtype2diabetespatientswereineludedinthestudy.AccordingtothepreseneeorabsenceofOSAS,wedividedthemintoOSASgroup(60cases)andnonOSASgroup(69cases)・Meanwhileweselected30healthyelderly-citizensasnormalcontro
7、lgrou.Allpatientswererecordedage,sex,heightandweight,andtestedIIs-CRP,Iley,TG,TC,LDL-CandCIMT.ComparingwiththedifferencesbetweentheOSASgroupandnonOSASgroup,whichwerecomparedwiththenormalcontrolgroup.AnalysisingthecorrelationofCIMTandcarotidplaquerespectivelywithHs-CRP
8、,Hey,TG,TC,LDL-C,ageandBMI.Results(l)TheHs-CRP,Hey,CIMT,TG,TC,LDL-ClevelsinOSASgroupwerehigherthanthoseinnormalcontrolgroup(
