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1、干扰素一a联合化疗治疗恶性黑色素瘤临床疗效观察［摘要］目的观察干扰素-a（INF-a）联合化疗治疗恶性黑色素瘤临床效果。方法选取2014年9月〜2015年11月间于我院住院治疗的晚期恶性黑色素瘤患者共84例，以随机数字表法均分为对照组及观察组，每组42例。对照组给予常规DDAVC化疗方案治疗，观察组加用干扰素联合注射用达卡巴嗪（DTIC）,观察两组血清免疫指标、临床疗效及不良反应。结果观察组化疗前后T淋巴细胞亚群活性比较差异无统计学意义（t=l・793、2.081>0.642、2.229,P>0.
2、05）；对照组化疗前后T淋巴细胞亚群活性水平比较差异具有统计学意义（t=9・264、7.839、5.633、&129,P<0.05）；两组治疗总有效率比较差异有统计学意义（x2=13.574,P<0.05）；治疗后两组患者均有不同程度的不良反应,观察组在恶心呕吐、白细胞减少、血红蛋白减少、肝功能及肾功能损伤发生率方面与对照组比较差异有统计学意义（x2=12.69、17.68、19.04、23.78、16.54,P<0.05)。结论干扰素-a联合化疗治疗恶性黑色素瘤具有明显疗效，可以在临床中推广使用
3、。［关键词］干扰素；恶性黑色素瘤；化疗；达卡巴嗪；T淋巴细胞亚群［中图分类号］R739.5［文献标识码］B［文章编号］1673-9701(2016)24-0100-04[Abstroct]ObjectiveToobservetheclinicaleffectsofinterferon-combinedwithchemotherapyinthetreatmentofmalignantmelanoma.MethodsAtotalof84pa/tientswithadvancedmalignantmel
4、anomawhowerehospitalizedinourhospitalfromSeptember2014toNovember2015wereselected.Theywereassignedtothecontrolgroupandtheobservationgroupviatherandomnumbertable,with42patientsineachgroup・ThecontrolgroupwasgivenregularDDAVCchemotherapy,andtheobservation
5、groupwasfurthergiveninterferoncombinedwithDTICforinjection.Serumimmunologicalindicators,clinicalcurativeeffects,adversereactionswereobservedbetweentwogroups・ResultsTheactivitiesofTlymphocytesubgroupbeforeandafterthechemotherapyintheobservationgroupwer
6、enotstatisticallysignificant(t=l.793，2.081,0.642,2.229,P>0・05)；theactivitiesofTlymphocytesubgroupbeforeandafterthechemotherapyinthecontrolgroupwerestatisticallysignificant(t=9.264,7.839,5.633,8.129,P〈0・05)；thetreatmenteffectiveratescomparedbetweenthet
7、wogroupswerestatisticallysignificant(x2=13.574,P<0.05)；differentdegreesofadversereactionswereobservedinbothgroupsofpatientsafterthetreatment,andtheincidenceratesofnauseaandvomit,leukopenia,decreaseinhemoglobin,anddamagesofliverfunctionandrenalfunction
8、comparedwiththoseinthecontrolgroupwerestatisticallysignificant(x2=12.69,17.68,19.04,23.78,16.54,P<0.05)・ConclusionInterferon-combinedwithche-motherapyinthetreatmerrtofmalignantmelanomahassignificantcurativeeffects,whichcanbepromotedinclinicala
