膳食纤维与体重控制.ppt

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1、张爱珍zhangAizhen浙江大学城市学院医学与生命科学学院膳食纤维与体重控制Dietaryfiberandweightmanagement膳食纤维与体重控制Dietaryfiberandweightmanagement膳食纤维摄入量与体重、体脂呈负相关Mostbutnotallobservationalstudiesshowedaninverse,sometimesdose-dependentrelationshipbetweenDFconsumptionandbodyweight水溶性膳食纤维和非水溶性膳食纤维富含膳食纤维的天然食物和膳食纤维制剂Ge

2、nerally,inhumanstudies,nocleardifferenceregardingweightgainhasbeenshownbetweensolubleandinsolubleDFandfermentableandnonfermentableDF,orbetweenfoodsnaturallyhighinDFandfibersupplementsEpidemiologicsupportthatDFintakepreventsobesityisstrong对体重控制效果类似膳食纤维与体重控制Dietaryfiberandweightmana

3、gement膳食纤维控制体重的可能机制1含亲水基团，吸水膨胀性饱腹感2粘性、吸附性延缓饥饿感34减少营养素吸收5改变肠道激素分泌在大肠内发酵代谢提供能量较少Interventionstudies：theadditionofdietaryfibergenerallydecreasesfoodintakeand,hence,bodyweight.Mechanisms：InducinggreatersatiationandsatietyDecreasingabsorptionofmacronutrientsAlteringsecretionofguthormon

4、esDecreasinginenergyintakeandbodyweightlossmechanisms国外的研究：膳食纤维与体重控制DietaryfiberandweightmanagementHowarthetal:meanvaluesforpublishedstudiesindicatethatconsumptionofanadditional14g/dayfiberfor>2daysisassociatedwitha10%decreaseinenergyintakeandbodyweightlossof1.9kgover3.8monthsmean

5、energyintakeinallstudieswasreducedto82%byhigherfiberintakeinoverweight/obesepeopleversus94%inleanpeople;bodyweightlosswas2.4kgversus0.8kgEpidemiologicsupportthatDFintakepreventsobesityisstrong补充DF14g/d能量摄入：减少10%（消瘦者：6%肥胖/超重者：18%）体重：减轻1.9kg（消瘦者：0.8kg肥胖/超重者：2.4kg）对超重/肥胖症患者减轻体重的效果优于健

6、康体重者obeseindividualsmayexhibitagreatersuppressionofenergyintakeandbodyweightloss实验各组大鼠体重的变化情况(g，)组别实验前体重第2周第6周空白对照组203.5±8.5264.4±19.7367.7±29.4高脂模型组202.2±9.4281.2±16.8☆☆401.7±33.2☆☆MCP低剂量组204.5±7.8287.3±13.1☆☆396.1±31.8☆☆MCP中剂量组203.6±7.3284.7±12.6☆☆398.3±21.5☆☆MCP高剂量组202.5±8.4276

7、.8±12.5☆383.2±30.9我们的研究：MCP对肥胖大鼠血脂及瘦素的调节StudyofDFinrat实验各组大鼠脏体比的变化情况(g，)组别3周后肝体比3周后肾体比6周后肝体比6周后肾体比空白对照组2.76±0.220.72±0.032.70±0.160.70±0.06模型对照组3.98±0.31☆☆0.76±0.044.45±0.68☆☆0.67±0.07MCP低剂量组4.06±0.30☆☆0.73±0.024.17±0.49☆☆0.66±0.06MCP中剂量组4.12±0.21☆☆0.74±0.043.93±0.38☆☆△0.64±0.05☆M

8、CP高剂量组4.04±0.45☆☆0.74±0.023.66±0.