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1、不同胎龄早产儿血脂生化指标的临床意义作者：尹力扬1,王红兵1,徐丽2,刘淑华1,董单位：1•徐州市第一人民医院儿科，江苏徐州;2.徐州市第一人民医院产科;3•徐州市第一人民医院检验科【摘要】目的通过测定不同胎龄早产儿血脂生化指标的变化，探讨其作为评价早产儿成熟度、营养状况及营养支持指标的临床意义。方法早产儿组30例在入院后12h内(出生后24h)采集股静脉血2ml,采血前2h未喂养及输液。足月儿组30例在胎儿娩出、清理呼吸道后即刻采脐带血2ml。测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白Al(ApoA
2、l)、载脂蛋白B(ApoB)等生化指标。结果早产儿组血清TC、TG、HDL-C、LDL-C、ApoAl、ApoB水平均低于足月儿组，2组之间差异具有统计学意义(P<0.01)o28〜31周的早产儿组血清TC、TG、HDL-C、LDL-C、ApoAl、ApoB水平均低于32〜36周的早产儿组，2组之间差异具有统计学意义(P<0.01)o结仑血脂生化指标可作为评价早产儿成熟度及营养状况的依据。检测血脂水平变化，对临床合理营养支持具有指导意义。【关键词】早产儿;血脂;成熟度;营养状况;营养支持Theclinicalsignificanceofbiochemicalindi
3、catorsforbloodlipidsinprematureinfantsatdifferentgestationalagesYINLiyangl*,WANGHongbingl,XULi2,LIUShuhual,DONGXuepingl,LIANGShilei3,ZHANGDakui2,LIWenbinl(1.DepartmentofPediatrics,XuzhouFirstPeople&prime:sHospital,Xuzhou,Jiangsu221002,China;2.DepartmentofObstetrics,XuzhouFirstPeople&priine;s
4、Hospital;3.LaboratoryCenter,XuzhouFirstPeople&prinie;sHospital)Abstract:ObjectiveBymeasuringthebiochemicalchangesinbloodlipidsinprematureinfantsofdifferentgestationalage,toexploretheirclinicalsignificanceasbiochemicalindexestoevaluatethematurity,nutritionalstatusandnutritionalsupportinpremat
5、ureinfants・Methods30prematureinfantsadmittedtohospitalweredesignatedastheprematuregroup・Bloodcollectionof2mlwasperformedfromthefemoralveinwithin12hoursafteradmission(24hoursafterbirth)・2hoursbeforebloodcollection,theprematureinfantsreceivednotransfusionorfeeding.30neonatesoftermdeliveryunder
6、wentbloodcollectionof2mlfromtheumbilicalcordimmediatelvafterdeliveryandairwayclearance・Determinationswereconductedonthebiochemicalindicatorsincludingserumtotalcholesterol(TC),triglyceride(TG),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C),apolipoproteinAl(Ap
7、oAl)andapolipoproteinB(ApoB)・ResultsSerumTC,TG,HDL-C,LDL-C,ApoAlandApoBlevelsintheprematureinfantgroupwerelowerthaninthematureneonategroup・Theresultshadstatisticaldifference(P<0.01).SerumTC,TG,HDL-C,LDL-C,ApoAlandApoBlevelsintheprematureinfantso
