不同胎龄早产儿血脂生化指标的临床意义

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1、不同胎龄早产儿血脂生化指标的临床意义作者：尹力扬，王红兵，徐丽，刘淑华，董雪萍，梁世磊，张大葵，李文斌【摘要】目的通过测定不同胎龄早产儿血脂生化指标的变化，探讨其作为评价早产儿成熟度、营养状况及营养支持指标的临床意义。方法早产儿组30例在入院后12h内(出生后24h)采集股静脉血2ml，采血前2h未喂养及输液。足月儿组30例在胎儿娩出、清理呼吸道后即刻采脐带血2ml。测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)等生化指标。结果早产儿组

2、血清TC、TG、HDL-C、LDL-C、ApoA1、ApoB水平均低于足月儿组，2组之间差异具有统计学意义(P<0.01)。28～31周的早产儿组血清TC、TG、HDL-C、LDL-C、ApoA1、ApoB水平均低于32～36周的早产儿组，2组之间差异具有统计学意义(P<0.01)。结论血脂生化指标可作为评价早产儿成熟度及营养状况的依据。检测血脂水平变化，对临床合理营养支持具有指导意义。【关键词】早产儿;血脂;成熟度;营养状况;营养支持　　Abstract:ObjectiveBymeasuringthebiochemicalchanges

3、inbloodlipidsinprematureinfantsofdifferent8gestationalage,toexploretheirclinicalsignificanceasbiochemicalindexestoevaluatethematurity,nutritionalstatusandnutritionalsupportinprematureinfants.Methods30prematureinfantsadmittedtohospitalweredesignatedastheprematuregroup.Bloodcolle

4、ctionof2mlwasperformedfromthefemoralveinwithin12hoursafteradmission(24hoursafterbirth).2hoursbeforebloodcollection,theprematureinfantsreceivednotransfusionorfeeding.30neonatesoftermdeliveryunderwentbloodcollectionof2mlfromtheumbilicalcordimmediatelyafterdeliveryandairwayclearan

5、ce.Determinationswereconductedonthebiochemicalindicatorsincludingserumtotalcholesterol(TC),triglyceride(TG),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C),apolipoproteinA1(ApoA1)andapolipoproteinB(ApoB).ResultsSerumTC,TG,HDL-C,LDL-C,ApoA1andApo

6、Blevelsintheprematureinfantgroupwerelowerthaninthematureneonategroup.Theresultshadstatisticaldifference(P<0.01).SerumTC,TG,HDL-C,LDL-C,ApoA1andApoBlevelsintheprematureinfantsof28-31weekswerelowerthaninthoseof32-36weeks.Thelevelsbetweenthetwosubgroupsofprematureinfantsweresta

7、tisticallydifferent(P<0.01).ConclusionBiochemicalindicatorsofbloodlipid8canbeusedasevidenceofmaturityandnutritionalstatusinprematureinfantsandthedeterminationofthevariationsinthelevelsofbloodlipidsplaystheroleofareasonableguidetoclinicalnutritionalsupport.　　Keywords：prematur

8、einfants;bloodlipids;maturity;nutritionalstatus;nutrit