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《Regional expression levels of drug transporters and metabolizing enzymes along the pig andhuman intestinal tract and comparison with Caco-2 cells猪和人肠道中药物转运蛋白和代谢酶的区域表格达水平及与Caco-2细胞的比较.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。
1、DMDFastForward.PublishedonFebruary2,2017asDOI:10.1124/dmd.116.072231Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.DMD#72231RegionalexpressionlevelsofdrugtransportersandmetabolizingenzymesalongthepigandhumanintestinaltractandcomparisonwithCaco-2cellsStefanF.
2、C.Vaessen,MarolaM.H.vanLipzig,RaymondH.HPieters,CyrilleA.M.Krul,HeleenM.Wortelboer,EvitavandeSteegDownloadedfromTNO,Zeist,TheNetherlands(M.M.H.L,C.A.M.K,H.M.W,E.S);InstituteforRiskAssessmentSciences,Utrecht,TheNetherlands(R.H.H.P);ResearchCentreTechnology&Innovation;InnovativetestinginLifescien
3、cesandChemistry,UniversityofAppliedSciences,Utrecht,TheNetherlandsdmd.aspetjournals.org(S.F.C.V,R.H.H.P,C.A.M.K)atASPETJournalsonAugust14,20181DMDFastForward.PublishedonFebruary2,2017asDOI:10.1124/dmd.116.072231Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.
4、DMD#72231Runningtitle:IntestinalexpressionoftransportersandenzymesCorrespondingauthor:Dr.EvitavandeSteegTNOUtrechtseweg48P.O.Box3603700AJZeistTheNetherlandsE-mail:evita.vandesteeg@tno.nlDownloadedfromPhone:+31888662322Numberoftextpages:20dmd.aspetjournals.orgNumberoftables:2Numberoffigures:4Num
5、berofsupplementaldata:3atASPETJournalsonAugust14,2018Numberofreferences:29NumberofwordsintheAbstract:253NumberofwordsinIntroduction:713NumberofwordsinDiscussion:1416Non-standardabbreviations:BCRP,breastcancerresistanceprotein;BSEP,bilesaltexportpump;GLUT1,glucosetransporter1;MCT,monocarboxylate
6、transporter;MDR1,multidrugresistancegene;MRP,multidrugresistance-associatedprotein;NTCP,Na-taurocholateco-transportingpolypeptide;OATP,organicanion-transportingpolypeptide;OCT,organiccationtransporter;PEPT1,peptidetransporter1;CYP,cytochromeP450;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfon
7、icacid;KRB,Krebs-RingerBuffer;SD,standarddeviation;SEM,standarderrorofthemean;DMEM,Dulbecco'sModifiedEagleMedium;UGT,Uridine5'-diphospho-glucuronosyltransferase2DMDFastForward.PublishedonFebruary2,2017asDOI:10.1124/dmd.116.072231T
