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1、F1000Research2017,6(F1000FacultyRev):1628Lastupdated:01SEP2017REVIEWOriginsandpathogenesisofMiddleEastrespiratorysyndrome-associatedcoronavirus:recentadvances[version1;referees:3approved]Stephen A. Goldstein,Susan R. WeissDepartment of Microbiology, Perelman School of Medicine, Univ
2、ersity of Pennsylvania, Philadelphia, PA, USAv1Firstpublished: 01 Sep 2017, 6(F1000 Faculty Rev):1628 (doi: OpenPeerReview10.12688/f1000research.11827.1)Latestpublished: 01 Sep 2017, 6(F1000 Faculty Rev):1628 (doi: 10.12688/f1000research.11827.1)RefereeStatus:AbstractInvited Referee
3、sMiddle East respiratory syndrome-associated coronavirus (MERS-CoV) has123been a significant research focus since its discovery in 2012. Since 2012, 2,040cases and 712 deaths have been recorded (as of August 11, 2017),version1representing a strikingly high case fatality rate of 36%.
4、 Over the last severalpublishedyears, MERS-CoV research has progressed in several parallel and01 Sep 2017complementary directions. This review will focus on three particular areas: theorigins and evolution of MERS-CoV, the challenges and achievements in thedevelopment of MERS-CoV an
5、imal models, and our understanding of howF1000 Faculty Reviews are commissionednovel proteins unique to MERS-CoV counter the host immune response. Thefrom members of the prestigious F1000origins of MERS-CoV, likely in African bats, are increasingly clear, althoughFaculty. In order t
6、o make these reviews asimportant questions remain about the establishment of dromedary camels as acomprehensive and accessible as possible,reservoir seeding human outbreaks. Likewise, there have been importantadvances in the development of animal models, and both non-human primatepe
7、er review takes place before publication; theand mouse models that seem to recapitulate human disease are now available.referees are listed below, but their reports areHow MERS-CoV evades and inhibits the host innate immune response remainsnot formally published.less clear. Although
8、 several studies ha
