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1、Downloadedfrommolecularcasestudies.cshlp.orgonFebruary7,2019-PublishedbyColdSpringHarborLaboratoryPressCOLDSPRINGHARBOR
2、RESEARCHREPORTMolecularCaseStudiesAnalysisofintrapatientheterogeneityuncoversthemicroevolutionofMiddleEastrespiratorysyndromecoronavirus1,2,93,91
3、,2,91,2DonghyunPark,HeeJaeHuh,YeonJeongKim,Dae-SoonSon,14333Hyo-JeongJeon,Eu-HyunIm,Jong-WonKim,NamYongLee,Eun-SukKang,5567CheolInKang,DooRyeonChung,Jin-HyunAhn,KyongRanPeck,4831,6SunShimChoi,Yae-JeanKim,Chang-SeokKi,andWoong-YangPark12SamsungGenomeInstitute,Samsun
4、gMedicalCenter,Seoul06351,SouthKorea;SamsungBiomedicalResearchInstitute,SamsungAdvancedInstituteofTechnology,SamsungElectronicsCompanyLimited,Seoul306351,SouthKorea;DepartmentofLaboratoryMedicineandGenetics,SamsungMedicalCenter,4SungkyunkwanUniversitySchoolofMedici
5、ne,Seoul06351,SouthKorea;DepartmentofMedicalBiotechnology,CollegeofBiomedicalScience,andInstituteofBioscience&Biotechnology,Kangwon5NationalUniversity,Chuncheon24341,SouthKorea;DivisionofInfectiousDiseases,SamsungMedical6Center,SungkyunkwanUniversitySchoolofMedicin
6、e,Seoul06351,SouthKorea;DepartmentofMolecular7CellBiology,SungkyunkwanUniversitySchoolofMedicine,Suwon440-746,SouthKorea;DepartmentofInternalMedicine,SamsungMedicalCenter,SungkyunkwanUniversitySchoolofMedicine,Seoul06351,8SouthKorea;DepartmentofPediatrics,SamsungMe
7、dicalCenter,SungkyunkwanUniversitySchoolofMedicine,Seoul06351,SouthKoreaAbstractGenomesequenceanalysisofMiddleEastrespiratorysyndromecoronavirus(MERS-CoV)variantsfrompatientspecimenshasrevealedtheevolutionarydynamicsandmechanismsofpathogenesisofthevirus.However,mos
8、tstudieshaveanalyzedtheconsensussequencesofMERS-CoVs,precludinganinvestigationofintrapatientheterogeneity.Here,weanalyzednon–consensussequencestocharacterizeintrapatientheterogeneityincasesassociatedwiththe2015outbreakofMERSinSouthKorea.Deep-sequencinganalysisofMER
9、S-CoVgenomesperformedonspecimensfromeightpatientsCorrespondingauthors:cs.ki@revealedsignificantintrapatientvariation;therefore,sequenceheterogene
