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1、AcceptedManuscriptSyntheticVirus-likeParticlesPreparedviaProteinCoronaFormationEnableEffectiveVaccinationinanAvianModelofCoronavirusInfectionHui-WenChen,Chen-YuHuang,Shu-YiLin,Zih-SyunFang,Chen-HsuanHsu,Jung-ChenLin,Yuan-I.Chen,Bing-YuYao,Che-MingJ.Hu
2、PII:S0142-9612(16)30404-5DOI:10.1016/j.biomaterials.2016.08.018Reference:JBMT17665Toappearin:BiomaterialsReceivedDate:15May2016RevisedDate:10August2016AcceptedDate:13August2016Pleasecitethisarticleas:ChenH-W,HuangC-Y,LinS-Y,FangZ-S,HsuC-H,LinJ-C,ChenY
3、-I,YaoB-Y,HuC-MJ,SyntheticVirus-likeParticlesPreparedviaProteinCoronaFormationEnableEffectiveVaccinationinanAvianModelofCoronavirusInfection,Biomaterials(2016),doi:10.1016/j.biomaterials.2016.08.018.ThisisaPDFfileofanuneditedmanuscriptthathasbeenaccep
4、tedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybedi
5、scoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPT1SyntheticVirus-likeParticlesPreparedviaProteinCorona2FormationEnableEffectiveVaccinationinanAvianModelof3CoronavirusInfection†§†‡††‡†4Hui-WenChen*
6、,Chen-YuHuang,Shu-YiLin,Zih-SyunFang,Chen-HsuanHsu,Jung-‡‡‡§‡5ChenLin,Yuan-IChen,Bing-YuYao,Che-MingJ.Hu*6†DepartmentofVeterinaryMedicine,NationalTaiwanUniversity,Taipei,Taiwan7‡InstituteofBiomedicalSciences,AcademiaSinica,Taipei,Taiwan8§ResearchCente
7、rforNanotechnologyandInfectiousDiseases,Taipei,Taiwan910*Correspondingauthors.Email:chu@ibms.sinica.edu.tw;winnichen@ntu.edu.tw111213KEYWORDSMANUSCRIPT14Proteincorona,virus-likeparticles,goldnanoparticles,coronavirus,infectiousbronchitisvirus,15spikep
8、roteins.1617181920ACCEPTED21221ACCEPTEDMANUSCRIPT23ABSTRACT24Theongoingbattleagainstcurrentandrisingviralinfectiousthreatshaspromptedincreasing25effortinthedevelopmentofvaccinetechnology.Amajorthrustinvaccineresearchfocuseson26developingformul
