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1、EurJClinMicrobiolInfectDis(2008)27:863–866DOI10.1007/s10096-008-0505-7CONCISEARTICLEMaterno-fetaltransmissionofhumancoronaviruses:aprospectivepilotstudyA.Gagneur&E.Dirson&S.Audebert&S.Vallet&M.C.Legrand-Quillien&Y.Laurent&M.Collet&J.Sizun&E.Oger&C.Pay
2、anReceived:23October2007/Accepted:3March2008/Publishedonline:29March2008#Springer-Verlag2008AbstractThisprospectivepilotstudyinvestigatestheIntroductionpossibilityofmaterno-fetaltransmissionofhumancorona-viruses(HCoV)responsibleforcasesofneonatalinfec
3、tion.Humancoronaviruses(HCoV)arepositive-strandedenvel-Thisverticaltransmissionwasstudiedwith159samplesopedRNAvirusesandwerediscoveredbyTyrrelBynoeinfrommother-childcouples:maternalvaginal(MV)andthe1960s[1].Twoserotypes,229-EandOC-43,arerespiratory(MR
4、)samplesduringlabor;andnewborngastricresponsibleforuptoone-thirdofcommoncoldsinadultssample(NG)withdetectionofHCoV(229E,OC-43,NL-[2].Sincetheidentificationofanewcoronavirusthatis63,HKU1)viarealtimeRTPCR.HCoVwasdetectedinresponsibleforsevereacuterespir
5、atorysyndrome(SARS)12samples(229E:11;HKU1:1)fromsevenmother-child[3],newtechnologicaltoolshaveenabledtherecentcouples.Forthreecouples,onlyMRtestedpositive(casesdiscoveryoftwonewHCoV:NL-63andHKU1[4,5].1–3).Fortwoothercouplesallthreesamples(MV,MRandTran
6、smissionofHCoV,likemanyotherviruseswithNG)testedpositive(cases4and5).Forcase6,onlyMVrespiratorytropism(rhinovirus,respiratorysyncytialvirus,andNGtestedpositive.Incase7,onlyMVwaspositive.humanmetapneumovirus),isinter-humanviarhinophar-Possibleverticalt
7、ransmissionofHCoVwashypothesizedyngealsecretions[6].WerecentlydescribedtheroleofinthispilotstudyandrequiresfurtherinvestigationonaHCoVincasesofnewbornnosocomialinfection[7–10].largerscale.Thesevirusesmaybeintroducedintothehospitalbypersonnel,visitors,
8、orhospitalizedchildren.Amaterno-fetaloriginmustneverthelessalsobeexploredbyTheexperimentsinthisstudycomplywiththecurrentlawsofFrancereasonofthefrequencyofthismodeoftransmissionregardingclinicalresearch.:::inanimalmodels[11]andtheexistenceofneo
