冠状病毒Coronavirusl论文-2005 Experimental Models of Multiple Sclerosis __ Coronavirus-Induced Demyelination and Spontaneous Remyelination.pdf

冠状病毒Coronavirusl论文-2005 Experimental Models of Multiple Sclerosis __ Coronavirus-Induced Demyelination and Spontaneous Remyelination.pdf

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时间:2020-03-16

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1、ChapterC8CORONAVIRUS-INDUCEDDEMYELINATIONANDSPONTANEOUSREMYELINATIONGrowthfactorexpressionandfunctionReginaC.Armstrong1'2,JeffreyM.Redwine2'3,andDonnaJ.Messersmith1'41DepartmentofAnatomy,Physiology,andGenetics,and2PrograminNeuroscience,UniformedServicesUnive

2、rsityoftheHealthSciences,4301JonesBridgeRd.,Bethesda,MD20814-4799;rarmstrong@usuhs.mil3Currentaffiliation:NeuromeInc.,LaJolla,CA920374Currentaffiliation:NationalCenterforBiotechnologyInformation,Bethesda,MD20894Abstract:MHV-A59coronavirusinfectionproducesatr

3、ansientepisodeofdemyelinationthatisfollowedbyspontaneousremyelination.ThisparadigmprovidesacomplexlesionenvironmenttoexaminecellularandmolecularmechanismsinvolvedinsuccessfulCNSremyelination.Ourworkinthismodelhasfocusedontherolesofplatelet-derivedgrowthfacto

4、randfibroblastgrowthfactor2inregulatingoligodendrocyteprogenitorresponsesrequiredforremyelination.Keywords:platelet-derivedgrowthfactor,fibroblastgrowthfactor,estrouscycle,gender,demyelinatingdisease,remyelination,coronavirus,cuprizone.INTRODUCTIONInsufficie

5、ntremyelinationresultsinprolongedneurologicalimpairmentindemyelinatingdiseasestates,suchasmultiplesclerosis.Acriticaldeterminantofremyelinationisregulationofoligodendrocytelineageresponses.Survivingand/ornewlygeneratedoligodendrocytelineagecellsmustberecruit

6、edtoappropriatesiteswithindemyelinatedtissuesandinducedtodifferentiateandformmyelin.Eachoftheseoligodendrocytelineagecellresponsesappearstoberegulatedbysignalswithinthelesionenvironment,suchasgrowthfactors,cytokines,andcell-cellinteractions.Thepathologyofmul

7、tiplesclerosis(MS)lesionsisheterogeneousbetweenpatients,withatleastfourfundamentallydifferentpatternsof794ChapterC8demyelination(12).Therefore,analysisofexperimentalmodelsofdemyelinationwithdistinctmechanismsofpathogenesisiswarranted.Inaddition,differentexpe

8、rimentalmodelshaveadvantagesforexaminingspecificaspectswithinthecourseofdemyelinatingdiseases.ThemousemodelofmurinehepatitisstrainA59(MHV-A59)coronavirusinfectionservesasarelevantmodelforanalyzi

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