资源描述：
《冠状病毒Coronavirusl论文-1996 Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、MvehBasicProteinandHumanCoronavirus229ECross-ReactiveTCellsinMultipleSclerosisPierreJ.Talbot,PhD,*Jean-SkbastienPaquette,BSc,*CristinaCiurli,MSc,?JackP.Antel,MD,$andFranceOuellet,BSc"Multiplesclerosis(MS)isaninflammatorydemyelinatingneurologicaldiseaseinwhichau
2、toreactiveTlymphocytessensitizedtomyelincomponentsofthecentralnervoussystemarepostulatedtocontributetopathogenesis.Thepossiblerelevanceofmolecularmimicrybetweenahumancoronavirusandthemyelinbasicproteincomponentofmyelininthegenerationofthisautoimmunereactionwase
3、valuated.Myelinbasicprotein-andvirus-reactiveT-celllineswereestablishedfrom16MSpatientsand14healthydonorsandshowntobemostlyCD4'.Incontrasttohealthydonors,severalT-celllinesisolatedfromMSpatientsshowedcross-reactivitybetweenmyelinandcoronavirusantigens.Overall,2
4、9%ofT-celllinesfromMSpatients(10donors)butonly1.3%ofT-celllinesfromnormalcontrolsubjects(2donors)showedanHLA-DR-restrictedcross-reactivepatternofantigenactivationafterinvitroselectionwitheithermyelinbasicproteinorhumancoronavirusstrain229Eantigens.Moreover,reci
5、procalreactivitieswereonlyobservedinMSpatients(4donors).Thisestablishesmolecularmimicrybetweenacommonviralpathogen,suchasthishumancoronavi-rus,andmyelinasapossibleimmunopathologicalmechanisminMSandisconsistentwiththepossibleinvolvementofmorethanoneinfectiouspat
6、hogenasanenvironmentaltriggerofdisease.TalbotPJ,PaquetteJ-S,CiurliC,AntelJP,OuellerF.Myelinbasicproteinandhumancoronavirus223scross-reactiveTcellsinmultiplesclerosis.AnnNeurol1996;39:233-240Multiplesclerosis(MS)isachronicdiseaseofthecen-lopedpositive-strandedRN
7、Avirusesarerespiratorytralnervoussystem(CNS)characterizedbymultifocalpathogensinvolvedinupto30%ofcommoncoldsregionsofinflammationandmyelindestruction[11.[7].AllknownhumanisolatescanbegroupedintoClinicaldiseaseonsetismostcommoninyoungadults.twoserotypes,designat
8、ed229EandOC43.SupportDiseaseprevalenceisunevenlydistributedgeographi-fortheirpossibleinvolvementinneurologicaldiseasescally.AvailableevidencesuggeststhattheetiologyofsuchasM
