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1、Eur.J.Immunol.1994.24:1383-1390MHVreceptoronBlymphocytesandmacrophages1383Jean-PaulCouteliero,BlymphocyteandmacrophageexpressionofCatherineGodfraind.,GabrielaS.DvekslerA,carcinoembryonicantigen-relatedadhesionMariaWysocka.,moleculesthatserveasreceptorsfor
2、murineChristineB.CardellichioA,HenriNoel.andcoronavirus*KathrynV.HolmesAUnitofExperimentalMedicine,Theexpressionofcarcinoembryonicantigen(CEA)-relatedglycoproteinsthatInternationalInstituteofCellularhavebeenassociatedwithintercellularadhesionandthatservea
3、sreceptorsforandMolecularPathologyoandmousehepatitisvirus(MHV)wasanalyzedincellsfromtheimmunesystemofLaboratoryofPathology.,St-LucBALB/cmiceusingimmunolabelingandRNApolymerasechainreactionHospital,CatholicUniversityofamplificationofreceptortranscripts.The
4、seglycoproteins,whicharecalledbiliaryLouvain,Brussels,Departmentofglycoproteins,werehighlyexpressedinBlymphocytes,includingcellsoftheB-laPathology,UniformedServices(CD5+)lineage,andinmacrophages,butwerenotdetectableinrestingUniversityoftheHealthSciencesA,
5、Tlymphocytes.Similarly,murinecelllinesofBcellandmacrophageoriginBethesdaandWistarInstitute,expressedmessengerRNAencodingCEA-relatedmolecules,whilethecorre-Philadelphia.spondingmRNAwasonlyslightlydetectableinaTcellline.TheseCEA-relatedcelladhesionglycoprot
6、einswerealsoexpressedinendothelialcells.Therefore,theirspecificinteractionwiththeirsofarunknownligandmaybeoffunctionalimportanceincellularinteractionsintheimmuneresponse.MonoclonalantibodydirectedagainsttheseglycoproteinsblockedMHV-A59infectionoftheBcell-
7、derivedSP20cellline.Thus,thefunctionalreceptorsforMHVonBlymphocytes,likethoseonmurinefibroblasts,areisoformsofCEA-relatedglycoproteins.TreatmentofBcellswithanti-receptorantibodyalsoblockedBcell-mediatedcytotoxicityagainstMHV-Ai59-infectedfibroblasts,indic
8、atingthatthisphenomenonismediatedbyinteractionofviralattachmentproteinontheinfectedtargetcellswithspecificCEA-relatedreceptorglycopro-teinsontheeffectorBcells.1Introductiontions[l].IntheIgsuperfamily,differentmousei
