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1、[FrontiersinBioscience11,2400-2419,September1,2006]CelladhesionmoleculesatthesynapseKimberlyGerrowandAlaaEl-HusseiniDepartmentofPsychiatry,UniversityofBritishColumbia,Vancouver,B.C.CanadaTABLEOFCONTENTS1.Abstract2.Introductiontothesynapse2.1.DevelopmentofNMJ2.2
2、.DevelopmentofCNSsynapses3.Roleofadhesionmoleculesinexcitatorysynapsedevelopment3.1.TargetRecognitionandInitiation3.2.RecruitmentofPresynapticandPostsynapticProteins3.3.MaturationandSpineMorphogenesis3.4.Elimination4.Celladhesionmoleculesimplicatedininhibitorys
3、ynapsedevelopment5.PlasticityandSignaling6.Modulationofcelladhesionmoleculesbyscaffoldingproteins7.Synapticimbalanceinpsychiatricdisorders8.Conclusions9.References1.ABSTRACT2.INTRODUCTIONTOTHESYNAPSESynapsesarespecializedintercellularIndevelopment,synapsesareth
4、oughttoformjunctionswhosespecificityandplasticityprovidethewhenmotilegrowthconesonthetipsofextendingaxonsstructuralandfunctionalbasisfortheformationandreachtheirtargetcellandaretransformedintostablemaintenanceofthecomplexneuralnetworkinthebrain.synapticcontacts
5、.ThisprocessrequiresspatiallyandThenumber,location,andtypeofsynapsesformedarewelltemporallycontrolledchangesincellshapeandstructurecontrolled,sincesynapticcircuitsareformedinahighlyandtherecruitmentofproteinstotheformingsynapse(1,reproducibleway.Thisimpliesthee
6、xistenceofcellularand2).Theaxonterminal,orpresynapticside,isengorgedwithmolecularpropertiesthatdeterminetheconnectivityofsynapticvesiclescontainingneurotransmitters,theeachneuroninthenervoussystem.Recentevidencehaschemicalbasisofneurontoneuroncommunication.Thes
7、eelucidatedthatthesekeyfeaturesofthesynapsearevesiclesaredockedonthepresynapticmembrane,attachedregulatedbyseveralfamiliesofcell-adhesionmoleculesbyacomplexcytomatrixofproteins,andprimedforthe(CAMs)enrichedatsynapticjunctions,includingpropersignalforrelease.Att
8、hedendrite,orpostsynapticneuroligins,SynCAM,NCAM,L1-CAM,cadherins,site,neurotransmitterreceptorsandawidearrayofprotocadherins,andintegrins.Inthisreviewwewilltransmembrane,cy
