2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension

2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension

ID:40705298

大小:1.45 MB

页数:11页

时间:2019-08-06

2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension_第1页
2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension_第2页
2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension_第3页
2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension_第4页
2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension_第5页
资源描述:

《2010 Cell adhesion integrating cytoskeletal dynamics and cellular tension》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库

1、REVIEWSCelladhesion:integratingcytoskeletaldynamicsandcellulartensionJ.ThomasParsons*,AlanRickHorwitz‡andMartinA.Schwartz*Abstract

2、Cellmigrationaffectsallmorphogeneticprocessesandcontributestonumerousdiseases,includingcancerandcardiovasculardisease.Formostcellsinmostenvironments,mo

3、vementbeginswithprotrusionofthecellmembranefollowedbytheformationofnewadhesionsatthecellfrontthatlinktheactincytoskeletontothesubstratum,generationoftractionforcesthatmovethecellforwardsanddisassemblyofadhesionsatthecellrear.Adhesionformationanddisassemblydrivethemigrationcyclebyac

4、tivatingRhoGTPases,whichinturnregulateactinpolymerizationandmyosinIIactivity,andthereforeadhesiondynamics.Themorphologicalfeaturesofmigratingcellscanvaryofcytoskeletalorganization,leadingtodirectionalcellBlebbingcellAcellthatextendsaround,considerably.Round,highlyprotrusiveorblebbi

5、ngcellsmovement.Thespatiallysegregatedmigrationmachin-dynamicprocessfromtheits(forexample,lymphocytesandcancercellsinsomeeryandthesignallingprocessesthatregulatethemaremembrane.environments)areatoneextremeandseemtomigrateintegratedbythecytoskeletonandvesicletrafficking,usingweakadh

6、esions.Highlyspreadcells(forexample,whichspantheentirecell.Substratecompliancefibroblastsandendothelialcells)areattheotherextremeAlthoughcellsexpressvariouscellsurfaceadhesionAmeasureoftheelasticityofthematerialtowhichcellsandhavemanylargeadhesions;theirmigrationisoftenreceptors(in

7、cludingintegrins,syndecansandotheradhereandisrelatedtothereferredtoasbeingmesenchymal.Inreality,thereisaproteoglycans,cadherinsandcelladhesionmolecules),distanceamaterialdeformscontinuumofmigrationmodesthatseemtobedeter-theintegrinfamilyoftransmembraneheterodimericunderforce.Itisth

8、einverseofminedbyseveralfactors,amongthemostimportantreceptorsisthebeststudiedandplaysaprominentpartstiffnessandisgiveninunitsbeingsubstratecompliance(andperhapsdimensionality)incellmigration20.Integrinextracellulardomainsbindof1perPascal.andtheintrinsiccontractilityofthecells.tosp

9、ecificsequencemotifspresen

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。