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1、ResearchinVeterinaryScience/988,45,383-388AttemptedimmunisationofcatsagainstfelineinfectlousperitonitisusingcaninecoronavirusC.A.STODDART,J.E.BARLOUGH,C.A.BALDWIN"',F.W.SCOTT,CornellFelineHealthCenterandDepartmentofVeterinaryMicrobiology,ImmunologyandParasi
2、tology,SchurmanHall,NewYorkStateCollegeofVeterinaryMedicine,CornellUniversity,Ithaca,NewYork14853-6401,USASpecificpathogenfreekittenswerevaccinatedwithanperitonitis(FlP),characterisedbyfibrinousperitonitisunattenuatedfieldisolateofcaninecoronavirus(ccv)orpl
3、euritisandformationofdisseminatedpyo•eitherbyaerosolorsubcutaneously,andreceivedgranulomas.Currenttherapies,usuallyconsistingofboostingvaccinationsfourweekslater.Aerosolisa•corticosteroidsorothermorepotentcytoreductivetionelicitedahomologousvirus-neutralisi
4、ng(VN)drugs,areonlypalliativeinnatureandinmostantibodyresponsethatincreasedsteadilyoverafour•instancesareineffectiveathaltingtherelentlesslyweekperiodandlevelledoffonetotwoweeksafterprogressivecourseofthedisease.revaccination.Theinitialaerosoliseddoseproduc
5、edAsafeandeffectiveFIPvaccinehasnotyetbeenanasymptomaticinfectionwithexcretionofeevdeveloped.Experimentsthusfarreportedusingfromtheoropharynxuptoeightdaysaftervaccina•variousviruseswithintheFIPVantigenicclustertion;virussheddingwasnotdetected,however,after(
6、Pedersenetal1978)havenotbeensuccessfulinthesecondinoculation.Catsvaccinatedsub•conferringuniformlyprotectiveimmunity(TomaetcutaneouslydevelopedlowVNantibodytitresafteral1979,WoodsandPedersen1979,Pedersenetalthefirsteevdoseandexperiencedastrong1981,1984,Pede
7、rsenandBlack1983,Barloughetalanamnesticresponseaftertheseconddose.Neutralls•1984b,1985,Pedersenandfloyd1985).Para•ingantibodytitresthenlevelledoffonetotwoweeksdoxically,becauseoftheimmunopathologicalnatureafterrevaccinationatmeanvaluessomewhatlowerofthedise
8、ase,vaccinationwithsomefelinecorona•thanincatsvaccinatedbyaerosol.eevwasnotviruseshasactuallypredisposedcatstothedevelop•isolatedfromtheoropharynxaftereithersub•mentofFIPandproducedamorerapidandcutaneo
