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1、BioEssaysVol.5,No.6257REVIEWARTICLESIntroductionofaselectablegeneintoprecursors.Nature318,149-154.primitivestemcellscapableoflong-term20LEMISCHKA,I.R.,RAULET,D.H.&ELIGILB0AisintheMolerularreconstitutionofthehemopoieticsystemofMULLIGAN,R.C.(1986).Development
2、alBiologyProgram,MemorialSIoanKetteringCancerCenter,NewW/Wvmice.Cell42,71-79.potentialanddynamicbehaviorofhemato-York,NewYork10021,USA.19KELLER,G.,PAIGE,C.,GILBOA,E.&poieticstemcells.Cell45,917-927.WAGNER,E.F.(1985).Expressionofa21ANDERSON,W.F.(1984).Prospe
3、ctsforforeigngeneinmyeloidandlymphoidcellshumangenetheraphy.Science226,401-409.derivedfrommultipotenthaematopoieticCoronavirusLeader-RNA-PrimedTranscription:anAlternativeMechanismtoRNASplicingMichaelM.C.LaiSummarymorphologicalandstructuralfeatures.'thesizem
4、oremRNAsaswellasvirionManyviralandcellularmRNAspeciesTheyconsistofanenvelopedvirusgenomicRNA.Thestructuralproteins,containaleadersequencederivedfromaparticlewithcharacteristicpetal-shapedtogetherwiththegenomicRNA,aredistantupstreamsiteonthesamegenebyspikes,
5、whichgiveanappearanceofausedtoassemblethevirusparticles.aprocessofRNAsplicing.Thisprocesscrown,orcorona,thusgivingthenameTheseparticles,unlikemostotherusuallyinvolveseithernuclearfunctionsforthevirus.Theviralenvelopecon-envelopedviruses,budintotheendo-orsel
6、f-splicingofRNAmolecules.Coro-tainstwoglycoproteins,oneofwhichplasmicreticulum,insteadofdirectlynavirus,acytoplasmicRNAvirus,un-formsthespikesandtheothertheintotheplasmamembrane.3Thefoldsyetanothermechanismofjoiningmatrixproteins.Thespikesinteractmatureviru
7、sparticlestravelthroughRNA,whichinvolvestheuseofafreewithvirusreceptorsonthecellsurface,theGolgicomplexandareeventuallyleaderRNAmolecule.Thismoleculeisthusdeterminingthetarget-cellspeci-releasedintotheextracellularspace.synthesizedanddissociatesfromtheficit
8、yofthevirus.InsidetheviralThevirusacquiresthevirus-specifictemplateRNA,andsubsequentlyreas-envelopeisahelicalnucleocapsidwhichglycoproteins,E1andE2,duringthesociateswiththetemplateRNAatdown-iscomposedo
