冠状病毒Coronavirusl论文-1986 4567042 Inactivated canine coronavirus vaccine.pdf

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1、PATENTABSTRACTS377duringthenitrogenfixation.SuchHupisob-4567042servedinanaturallyoccurringstrainofRhizobiumleguminosarumbutitwasnotINACTIVATEDCANINEknownhowtotransferittootherstrains.TheCORONAVIRUSVACCINEpresentinventionprovidesrecombinantplas-raidsplJl008andplJi00

2、7whichenableittobeWilliamMAcree,BobbyEdwards,JohnWtransferred.TheseplasmidsareformedfromaBlackassignedtoAmericanHomeProductstransmissibleplasmid,synthesizedtoincludeaCorporationdrug-resistancemarker,andaplasmidofthenaturallyoccurringstrain.CulturescontainingAneffic

3、aciousparenterallyadministeredin-theplasmidshavebeendepositedinacultureactivatedcaninecoronavirusvaccinewhichpro-collectionandcanbeused,afterappropriatefur-videssystemic,humoralprotectionandalsothercrossesasdescribed,toimpartHuptootherprotectionoftheintestinaltract

4、indogsfromin-strainsofRhizobium.Inaddition,culturescon-fectionbyvirulentcaninecoronavirusispro-tainingthestartingtransmissibleplasmidsdueed.Amethodforpropagationofthecanine(pVWSJIandpVW3JI)havebeendepositedandcoronavirusanditsattenuationandamethodofcanbeusedtoprepa

5、restrainsofRhizobiumcon-evaluatingtheeffectivenessofacaninetainingthesameorsimilarrecombinantplas-coronavirusvaccineincaninesisalsodisclosed.mids.Plantgrowthanalysisinlaboratorytestsdemonstratethatrhizobialstrainscontainingtheserecombinantnodulationplasmidswhichcon

6、ferHup+abilityaresuperiortothecor-4~7043respondingRhizobiumfieldisolatesintermsofoverallplantgrowthdependentonsymbioticnitrogenfixation.CANINECORONAVIRUSVACCINEWilliamMAcre:,BobbyEdwards,JohnWBlackassignedtoAmericanHomeProductsCorporation(Del)Anefficaciousparentera

7、ilyadministeredmodifiedliveCanineCoronavirusvaccinewhichprovidessystemic,humoralprotectionandalsoprotectionoftheintestinaltractindogsfrominfectionbyvirulentCanineCoronavirus4568362isproduced.AmethodforpropagationoftheCanineCoronavirusanditsattenuationandaGASIFICATI

8、ONMETHODANDmethodofevaluatingtheeffectivenessofaAPPARATUSFORCanineCoronavirusvaccineincaninesisalsoLIGNOCELLULOSICPRODUCTSdisclosed.XavierDeglise