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1、ResearchinVeterinaryScience1991,51,11-18CaninecoronavirusinfectioninthedogfollowingoronasalinoculationB.J.TENNANT,R.M.GASKELL,D.F.KELLY,S.D.CARTER,DepartmentofVeterinaryPathology,C.J.GASKELL,DepartmentofVeterinaryClinicalScience,UniversityofLiverpool,Liverpool,L693BXT
2、hepathogenesisofcaninecoronavirus(ccv)Systemicspreadofccvhasnotbeenwellstudiedinfectionin10-week-oldpuppieswasstudiedupto14althoughtherearesome,oftenanecdotal,reportsofdaysafteroronasalinoculation.Milddiarrhoeawasvirushavingbeendemonstratedinvarioustissuesseenfromthre
3、eto11daysafterinoculation,approx-includingmesentericlymphnodes,liver,spleen,imatelycoincidentwithfaecalvirusshedding.Virusmeningesandlung(Keenaneta11976,Binneta11979,wasinitiallyisolatedfromthetonsilsonday3,andGreene1984,Acreeetal1985).ccvhasalsobeenthenfrombothsmalla
4、ndlargeintestinaltissuesuptoimplicatedinapancreatitis/meningitissyndrome14daysafterinoculation.Viruswasalsoisolatedfollowingliveccvvaccination(Martin1985,Wilsonfromliverandlung.Histologicalchangeswerenotetal1986)andccvhasalsobeenshowntocauseseeninanytissues,butccvanti
5、genwasdetected,systemicinfectioninthecat(McArdleetal1991).usingaperoxidaseantiperoxidasestainingtechnique,Othercoronaviruses,includingthecloselyrelatedmainlyinepitheliumoverlyinggut-associatedfelineinfectiousperitonitisvirusandtransmissiblelymphoidtissue.Virusneutrali
6、singantibodywasfirstgastroenteritisvirusofpigs,havealsobeenfoundtodetectedonday10.Specificanti-ccvIgMwasfirstaffectvariousorgansystemsinadditiontothegutdetectedinplasmathreedaysafterinoculationand(HooperandHaelterman1969,Mebusetal1973,IgGondays4to7.Smallamountsofanti-
7、ccvIgG,Underdahletal1974,Pedersenetal1984,WeissandIgMandIgAweredetectedinduodenalsecretion,butScott1981,Thomasetal1982,Childsetal1983).noneinbile.AsthepublishedworkonthepathogenesisofccvinfectionismainlybasedonexperimentalinfectionofALTHOUGHcaninecoronavirus(ccv)hasbe
8、enneonatalpups,thepresentworkwasundertakeninrecognisedsince1971(Binnetal1974)inassociationolder,10-week-oldpups,inordertorep
