肝癌预后危险因素.doc

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1、clinicopathologicalfactorsAge≤65>65SexMFPresentationSubclinicalSymptomaticHepatitisBsurfaceantigenPositiveNegativeHepatitisCantibodyPositiveNegativeDualinfectionPositiveNegativeChildclassificationGradeAGradeBPreoperativeICGR-15min(%)≤15>15SerumUreanitrogen(mg/dl)≤21>21SerumCreat

2、inine(mg/dl)≤1.4>1.4SerumAlbumin(g/dl)≤3.5>3.5SerumAlkalinephosphatase(U/L)≤94>94SerumAspartateaminotransferase(U/L)≤34>34SerumAlanineaminotransferase(U/L)≤36>36SerumTotalbilirubin(mg/dl)≤2.0>2.0Plateletcount(≤109/L)≤150>150Prothrombintime/prolong(s)≤4.0>4.0Extentofresection（Typ

3、eofresection）MajorhepatectomyMinorhepatectomyMajorresectionisdefinedasresectionof≥threesegments,minorresectionasresectionof≤twosegments.Bloodloss(L)≤4>4BloodtransfusionNoYesMorbidityNoYesAFP≤20>20RuptureNoYesTumorsize(cm)≤2？5？>2？5？SatellitelesionsNoneYesResectionmargin(cm)≤1>1Ca

4、psularformationPositiveNegativeCapsularinvasionNoYesVascularinvasionNoYesDiploidystatusYesNoTumornumberSolitaryMultipleMacroscopicresectionmargin≤1cm＞1cmMicroscopicresectionmarginPositiveNegativeMicroscopicvenousinvasionNoYesTumorencapsulationNoYespTNMstage≈IIIIIIAIVAAbbreviatio

5、n:pTNMstage,pathologictumor-node-metastasisstage.1对于乙肝患者而言，术前HBV-DNA水平的影响很重要！此外，肝硬化、肝纤维化程度的影响！Thefollowingclinicopathologicvariablesthatmightcorrelatewithdisease-freesurvivalandrecurrencerateswereevaluated:2presenceofHBsAgmarker,presenceofanti-HCVantibodies,Childclassification,[

6、alpha]-fetoproteinlevel,diameterofnodules(<5cmvs.>5cm),numberofnodules(singlevs.multiple),preoperativeintra-arterialchemoembolization,typeofresection,intraoperativebloodtransfusion,micro-ormacroscopicportalveininfiltration,presenceoftumorcapsule,preoperativeaspartateaminotransfe

7、rase(AST)andalanineaminotransferase(ALT)levelsHBsAgpositive32(14.3%)16%77%NSHBsAgnegative192(85.7%)37%51%HCVpositive129(57.6%)45%59%NSHCVnegative36(16.1%)14%48%Alpha-fetoprotein_20ng/mL110(49%)27%45%NSAlpha-fetoprotein_20ng/mL114(51%)44%61%ChildA185(82.6%)36%59%NSChildB_C39(17.4

8、%)30%36%Singlenodule200(89.1%)32%52%_.01Multipl