资源描述：
《血清铁调素含量在鉴别缺铁性贫血和慢性病贫血中的意义.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、血清铁调素含量在鉴别缺铁性贫血和慢性病贫血中的意义汝赵晋英'周沛2刘翠彳曾漂彳岳云彳谢奔2胡晓娇2(1邵阳医学高等专科学校检验系湖南邵阳422000；2邵阳医学高等专科学校检验系2008级学生湖南邵阳422000)【摘要】目的评价血清铁调素(Hepc)含量在鉴别诊断缺铁性贫血(IDA)和慢性病贫血(ACD)中的意义。方法采用酶联免疫吸附法(ELISA)检测36例IDA患者和33例ACD患者血清Ilepc含量，与同期22例健康体检者血清Ilepc含量进行比较。结果正常对照组血清Hepc含量为49.50±29.80ng/ml,IDA患者血清Ilepc含量为19.73±15.62ng/
2、ml,比正常组降低60.14%,具有统计学意义(P<0.01);而ACD患者血清Ilepc含量明显增高，达119.45±50.97ng/ml,比正常对照组增高了141.31%(R0.01)。IDA组血清Hepc与Hb之间呈正相关(r=0.704,P<0.01);ACD组血清Hepc与Hb之间呈负相关(r=-0.595,P<0.01X结论IDA时血清Ilepc含量降低，而ACD时血清Ilepc含量升高，并且其变化程度与患者贫血程度相关。血清Ilepc含量对于鉴别诊断IDA和ACD及治疗具有重要的意义。【关键词】缺铁性贫血；慢性病贫血；铁调素；血红蛋白中图分类号：R556.3Thed
3、iagnosticvalueofserumhepcidininthedifferentialdiagnosisofirondeficiencyanemiaandanemiaofchronicdiseasesZhaojinying,Zhoupci,Liucui，Zengpiao,Yucyun,Xieben,Huxiaojiao,Huangzezhi(DepartmentofEcsomatics;ShaoyangMedicalCollege;HunanShaoyang422001;China)[Abstract]Objectives:Toclarifythediagnosticval
4、ueofserumhepcidin(Hepc)inthedifferentialdiagnosisofirondeficiencyanemia(IDA)andanemiaofchronicdiseases(ACD).Methods:TheserumHepcconcentrationofIDA(36cases),ACD(33cases)andhealthcontrol(22cases)weredetectedbyELISA.Results:TheconcentrationofserumHepcinhealthcontrol,IDAandACDwere49.50±29.80ng/ml
5、,19.73±15.62ng/mland119.45±50.97ng/ml,respectively.Ascomparedwithcontrol,theconcentrationofserumHepcinIDAwasdecreased60.14%,whiletheconcentrationofserumHepcinACDwasincreased141.31%・CorrelationanalysisshowedtheconcentrationofsemmHepcinIDAcorrelatepostivelywithHbconcentration(r=0.704,P<0.01),wh
6、ileinACDcorrelatenegativelywithHbconcentration(r=-0.595,P<0.01).Conclusions:TheconcentrationofserumHepcdecreasedinIDA,whileincreasedinACD・ThischangeofserumHepcconcentrationwasrelatedwiththedegreeofanemiaofpatients.ItissignificantandvaluabletodetectserumHepcconcentrationforthedifferentialdiagn
7、osisbetweenIDAandACD.[KeyWords]irondeficiencyanemia,anemiaofchronicdiseases^hepcidin，Hb※基金项目：2009年湖南省大学生研究性学习和创新性实验计划项目(483号)作者简介：赵晋英(1979・9-)，女・硕士，讲师，系课题指导老师。E-mail:zhaojinying928@I63.com.贫血作为临床常见的血液病，其病因和发病机制不同，治疗方法也不一样，因此鉴别诊断各型贫血尤为重要。特别是缺铁
