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时间:2020-03-21
《血清亲环素 A与急性动脉粥样硬化性脑梗死关系研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、淮海医药》2014年5月第32卷第3期JHuaihaiMed,May2014,Vo1.32,No.3血清亲环素A与急性动脉粥样硬化性脑梗死关系研究王茂林,汪恩焕,周钟阳,马骥,王宏伟,张妮娜【摘要】目的联合检测急性动脉粥样硬化性脑梗死患者血清亲环素A(CyPA)、基质金属蛋白酶一9(MMP-9)和高敏c反应蛋白(hs.CRP)表达,探讨三者在急性动脉粥样硬化性脑梗死中的作用。方法观察组为急性动脉粥样硬化性脑梗死患者60例,选取我院同期体检证实为健康者60例为对照组。采用ELISA法检测2组患者血清中CyPA及MMP-9浓度,采用乳胶免疫比浊法检测2组
2、血清中hs-CRP浓度,进行统计学分析。结果观察组血清中CyPA、MMP.9和hsCRP浓度明显高于对照组(P<0.001)。观察组患者血清中CyPA与MMP-9浓度呈正相关(r=0.64,P<0.001);观察组患者血清中CyPA与hs.CRP浓度呈正相关(r=0.71,P<0.001);观察组患者血清中MMP-9与hs—CRP浓度呈正相关(r=0.61,P<0.001)。结论急性脑梗死患者血清CyPA、MMP一9和hs-CRP浓度显著升高,其可能与患者动脉粥样硬化斑块稳定性相关。【关键词】急性脑梗死;动脉粥样硬化;亲环素A;基质金属蛋白酶一9;高
3、敏c反应蛋白【中图分类号】R541.4【文献标识码】A【文章编号】1008-7044(2014)03-0221-02RelationofcyclophilinAandacuteatherothromboticcerebralinfarctionWANGMao-Z,WANGEn—huan,ZHOUZhong-yang,eta1.(DepartmentofNeurosurgery,BengbuThirdPeople'sHospital,Anhui233000,China)【Abstract】ObjectiveToexploretheroleofcyclo
4、philinA(CyPA),matrixmetalloproteinase-9(MMP-9)andhighsensi-tiveC.reactiveprotein(hs—CRP)inpatientswithacuteatherothromboticcerebralinfarction.Methods60patientswithacuteatherothromboticcerebralinfarctiontreatedinourhospitalwereselectedasanobservationgroup.Meanwhile,another60peop
5、leconfirmedtobehealthybyphysicalexaminationwereselectedasacontrolgroup.TheserumlevelsofCyPAandMMP一9weremeasuredbyELISA。andtheserumlevelofhs.CRPwasmeasuredbyimmunecolorimetricmethod.ResultsTheserumCyPA,MMP一9andhs—CRPconcentrationintheobservationgroupweresignificantlyhigherthanth
6、oseinthecontrolgroup(P<0.001).SerumCyPAwascorrelatedpositivelywithserumMMP一9andhs—CRPinthepatientswithacuteatherothromboticcer-ebralinfarction(r1=0.64,r2=0.71,P<0.001,P<0.001,respectively).SerumMMP-9wascorrelatedpositivelywithserumhs-CRPinpatientswithacuteatherothromboticcerebr
7、alinfarction(r3=0.61,P<0.001),butnotpeopleinthecontrolgroup.ConclusionTheincreaseofserumCyPA,MMP一9andhs—CRPlevelsmightbesignificantlycorrelatedwiththestabilityofca—rotidplaques.【Keywords】Acutecerebralinfarction;Atherosclerosis;CyclophilinA;Matrixmetalloproteinase一9;Highsensitiv
8、eC—reac一急性脑梗死(ACI)的发病率、复发率及致死率高,临床危脉血3ml,分离血清,置于一80%冰箱
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