冠状病毒Coronavirusl论文-2016 Identification of a Lineage D Betacoronavirus in Cave Nectar Bats (_ _i_Eonycteris spelaea__i__.pdf

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1、TransboundaryandEmergingDiseasesORIGINALARTICLEIdentificationofaLineageDBetacoronavirusinCaveNectarBats(Eonycterisspelaea)inSingaporeandanOverviewofLineageDReservoirEcologyinSEAsianBats11111121I.H.Mendenhall,S.Borthwick,E.S.Neves,D.Low,M.Linster,B.Liang,M.Skiles,J.Jayakumar,33

2、4,5113,61H.Han,V.Gunalan,B.P.Y.-H.Lee,K.Okahara,L.-F.Wang,S.Maurer-Stroh,Y.C.F.Suand1,7G.J.D.Smith1ProgrammeinEmergingInfectiousDiseases,Duke-NUSMedicalSchool,Singapore2CollegeofVeterinaryMedicine,NorthCarolinaStateUniversity,Raleigh,NC,USA3BioinformaticsInstitute,AgencyforSc

3、ience,TechnologyandResearch,Singapore4DurrellInstituteofConservationandEcology,SchoolofAnthropologyandConservation,UniversityofKent,Canterbury,UK5NationalParksBoard,Singapore6SchoolofBiologicalSciences,NanyangTechnologicalUniversity,Singapore7DukeGlobalHealthInstitute,DukeUni

4、versity,Durham,NC,USAKeywords:Summarydiseaseecology;virusdiversity;evolution;distributionCoronavirusesareadiversegroupofvirusesthatinfectmammalsandbirds.BatsarereservoirsforseveraldifferentcoronavirusesintheAlphacoronavirusandCorrespondenceBetacoronavirusgenera.Theyalsoappear

5、tobethenaturalreservoirfortheances-I.H.MendenhallandG.J.D.Smith.tralvirusesthatgeneratedthesevereacuterespiratorysyndromecoronavirusandProgrammeinEmergingInfectiousDiseases,MiddleEastrespiratorysyndromecoronavirusoutbreaks.Here,wedetectedcoro-Duke-NUSMedicalSchool,Singapore.n

6、avirussequencesinnext-generationsequencedatacreatedfromEonycterisTel.:+6566011109;Fax:+6562212529;spelaeafaecesandurine.WealsoscreenedbyPCRurinesamples,faecalsamplesE-mails:ian.mendenhall@duke-nus.edu.sgandgavin.smith@duke-nus.edu.sgandrectalswabscollectedfromsixspeciesofbats

7、inSingaporebetween2011and2014,allofwhichwerenegative.ThephylogeneticanalysisindicatesthisnovelstrainismostcloselyrelatedtolineageDBetacoronavirusesdetectedinadiverseReceivedforpublicationApril26,2016rangeofbatspecies.Thisisthesecondtimethatcoronaviruseshavebeendetectedincaven

8、ectarbats,butthefirstcoronavirussequencedatageneratedfromthisdoi:10.1