冠状病毒Coronavirusl论文-2018 Tissue Distribution of the Mers-Coronavirus Receptor in Bats.pdf

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1、102ESVP,ESTPandECVPProceedings2017J.Comp.Path.2018,Vol.158,93e149BLINDNESSANDSUDDENDEATHINTURKEYSTISSUEDISTRIBUTIONOFTHEMERS-CORONAVIRUSyzA.Lehmbecker*,L.Zind*,P.Wolf,P.Bahrenberg,RECEPTORINBATSzxxxC.Mandischer,E.vanderVries,W.K.JoLei,A.OsterhausA.Widagdo*,L.Begeman*,D.Schip

2、per*,P.R.vanRun*,yzandW.Baumgartner€*A.A.Cunningham,N.Kley,C.B.Reusken*,*DepartmentofPathology,UniversityofVeterinaryMedicineHannover,B.L.Haagmans*andJ.M.A.vandenBrand*Foundation,yChairofNutritionPhysiologyandAnimalNutrition,University*DepartmentofViroscience,ErasmusMedicalCe

3、nter,Rotterdam,ThezxyofRostock,VeterinaryPracticeG€uterstrasse,HamminkelnandResearchNetherlands,InstituteofZoology,ZoologicalSocietyofLondon,London,UKzCenterforEmergingInfectionsandZoonoses,UniversityofVeterinaryandInstituteforNovelandEmergingInfectiousDiseases,FriedrichLoeffl

4、erMedicineHannover,Foundation,Hannover,GermanyInstitute,Greifswald,GermanyIntroduction:SeveralcasesofpoultryexhibitingblindnessandsignsIntroduction:MiddleEastrespiratorysyndromecoronavirusaffectingthecentralnervoussystemarereported.Theaetiologyof(MERS-CoV)hasbeenshowntoinfect

5、bothmananddromedarythisdiseaseremainsundeterminedsofar.Variousaetiologiessuchcamelsusingdipeptidylpeptidase-4(DPP4)asitsreceptor.Thedis-asinfections,intoxicationsordeficienciesarediscussed.tributionofDPP4intherespiratorytracttissuesofmanandcamelsMaterialsandMethods:Sixanimalsw

6、ereclinically,macroscopi-reflectsMERS-CoVtropism.Apartfromdromedarycamels,insectiv-cally,histologicallyandimmunohistologicallyinvestigated.ThedietorousbatsaresuggestedasanothernaturalreservoirforMERS-like-underwentadetailedanalysiswithrespecttomineralsandheavyCoVs.metals,metha

7、nol,vitaminA,coccidiostats,pesticidesandaminoacids.MaterialsandMethods:InordertogaininsightonthetropismofResults:Affectedanimalsshoweddisturbedbalanceandgaitabnor-thesevirusesinbats,westudiedtheDPP4distributionintherespira-malities.Macroscopicallybilateralsymmetricalmalaciawa

8、sevident,toryandextra-respiratorytissuesoftwofrugivorousbatspecies(E