冠状病毒Coronavirusl论文-2007 Coronavirus NL63 Illnesses in Infancy are a Risk Factor for Asthma at Age Six.pdf

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1、S146AbstractsJALLERGYCLINIMMUNOLJANUARY2007CoronavirusNL63IllnessesinInfancyareaRiskFactorforp50.005)prevalenceinchildrenwhoneededtobenebulized(n518,574AsthmaatAgeSix25.7%)comparedwithstable(n57,8.8%)asthmatics.1111CONCLUSIONS:Rhinovirusisthemajorviraltrigger

2、forpediatricT.E.Pappas,K.T.SullivanDille,W.Lee,K.A.Grindle,K.A.Ro-11111berg,D.F.DaSilva,C.J.Tisler,E.L.Anderson,K.M.Hansen,R.A.asthmainTrinidadandisnotassociatedwithseasonalityinthistropical11221climate.Grabher,L.E.PleissSalazar,M.D.Evans,R.Gagnon,J.E.Gern,11

3、Funding:TheUniversityoftheWestIndiesandUniversityofWisconsin-R.F.Lemanske,Jr.;UniversityofWisconsinSchoolofMedicineand2MadisonPublicHealthMadison,WI,UniversityofWisconsinPopulationHealthSciencesBiostatisticsandMedicalInformatics,Madison,WI.AnalysisofAirwayImm

4、uneSystemResponsestoRhinovirusRATIONALE:Ininfancy,rhinovirusillnessesandsevereRSVbronchiol-576InfectioninChildrenandResultantTendencytoWheezeitisindicateincreasedriskforrecurrentwheezingandasthma,butthereis12223B.K.Smith,C.J.Tisler,T.E.Pappas,D.Mueller,D.F.Da

5、Silva,lessinformationaboutotherviruses.Weevaluatedthefrequencyandse-441J.E.Gern,R.F.Lemanske,Jr.;UniversityofWisconsinSchoolofMed-verityofmetapneumovirus(HMPV)andcoronavirus(HCV)infections2icineandPublicHealthMadison,WI,UniversityofWisconsinHospital,inahigh-r

6、iskgroupofinfants.34Madison,WI,UniversityofWisconsinHospital,Madison,WI,Univer-METHODS:Nasallavagesampleswereobtainedinthefirstyearoflifedur-sityofWisconsin,Madison,WI.ingscheduledstudyvisitsandsymptomaticrespiratoryillnessesaspartofRATIONALE:Wehypothesizethat

7、childrenidentifiedaswheezerswilltheChildhoodOriginsofAsthmaProject(COAST).Samples(n5567)presentwithincreasedlevelsofinflammatorycytokinesanddecreasedwereanalyzedbyRespiratoryMulticodeAssay(RMA)forHMPV,HCV-levelsofanti-viralcytokinesinnasallavagesamplesduringsym

8、ptomaticSUNDAY229E,HCV-OC43,HCV-NL63andHCV-SARS.RVinfectioncomparedtonon-wheezersduringsymptomaticRVinfection.RESULTS:HMPVwasisolatedin10.7%ofsamplesduringillnesses(n5METHODS:Totestthishy