冠状病毒Coronavirusl论文-2005 HUMAN CORONAVIRUS NL63 ASSOCIATED WITH LOWER RESPIRATORY TRACT SYMPTOMS IN EARLY LIFE.pdf

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1、BRIEFREPORTS9sions,andplateletsreachedaminimumvalueof8610/L.AACUTERESPIRATORYDISTRESSSYNDROMEINAcoagulationstudyrevealedaprolongedactivatedpartialthrombo-CHILDWITHHUMANPARVOVIRUSB19INFECTIONplastintimeandprothrombintime:47.1and16.8seconds,respec-Cla´udiaFerraz,MD,*FranciscoCunha,MD,tively.Liverfunc

2、tiontestswereabnormal;maximumtotalbilirubinTeresaC.Mota,MD,Jose´M.Carvalho,MD,andtransaminaseswere4.5and2.1timesnormal,respectively.JoanaS.Simoes,TotalWBCcountsremainednormalwithlymphocytopeniaduringMD,andJose´M.Aparicio,PhD§first5days.C-reactiveproteincontinuedtoriseuntilday6toaAbstract:A6-year-oldg

3、irldevelopedshockandmultipleorganmaximumof50.6mg/dL.dysfunctionincludingacuterespiratorydistresssyndromeinasso-Onthefourthday,therashwasmoreconfluentwithtargetciationwithparvovirusB19infection.Thediagnosiswasbasedonlesions.Askinbiopsyrevealedangiocentricdermatitiswithmod-positiveantibodiesandthedetec

4、tionofparvovirus19DNAineratemononuclearperivascularinfiltrateofthedermisandintravas-serum,bronchialsecretionsandskinbiopsy.Itseemslikely,butitcularpolymorphmargination.Intravenousimmunoglobulin(IVIG)wasnotproved,thattheparvovirusinfectioncausedacuterespira-400mg/kg/dwasadministeredfor5days.Theliverwa

5、sslightlytorydistresssyndrome.homogeneouslyenlargedbyabdominalultrasonography.Atrans-thoracicechocardiogramwasnormal.TherespiratoryconditiondidKeyWords:humanparvovirusB19,multipleorgandisfunctionnotimprove,andinhalednitricoxidewasdeliveredfor6dayssyndrome,acuterespiratorydistresssyndrome,nitricoxide

6、(maximum,20ppm;methemoglobin,1%).AcceptedforpublicationApril21,2005.Blood,urineandbronchialsecretionbacterialculturesre-Fromthe*DepartmentofPediatrics,PedroHispanoHospital,Matosinhos,mainednegative.Rickettsiaconorii,Borreliaburgdorferi,CoxiellaPortugal;andthePediatricIntensiveCareUnit,DepartmentofP

7、ediat-burnetii,Ehrlichia,Chlamydiapneumoniae,Mycoplasmapneu-rics,andtheMolecularBiologyLaboratory,DepartmentofClinicalmoniae,Leptospira,Pneumocystiscarinii,respiratoryvirus,cyto-Pathology,SaoJoaoHospi