资源描述：
《冠状病毒Coronavirusl论文-1975 Age-Dependent Resistance to Transmissible Gastroenteritis of Swine_ III_ Effects of Epithelial Cell Kinetics on Cor.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Vet.Pathol.12:434-445(1975)Age-DependentResistancetoTransmissibleGastroenteritisofSwine111.EffectsofEpithelialCellKineticsonCoronavirusProductionandonAtrophyofIntestinalVilliH.W.MOON,L.J.KEMENY,G.LAMBERT,S.L.STARKandG.D.BOOTHU.S.DepartmentofAgriculture,AgriculturalResearchSer
2、vice,NationalAnimalDiseaseCenter,Ames,IowaAbstract.Coronavirustitersinsmallintestine,degreeofvillousatrophyandapparentratesofregenerationofintestinalvilliwerecomparedinnewborn,3-week-oldandadultpigsfor1weekaftertheywereexposedtothetransmissiblegastroenteritisvirusofswine.Ther
3、esponsewithinthenewborngroupwashomogeneous,resultinginhighvirustiters,maximalvillousatrophyandcomparativelyslowregeneration.Ingeneral,virustiterswerelower,villousatrophywaslesssevereandregenerationmorerapidinbotholdergroupsthaninthenewbornpigs.However,theresponsevariedgreatly
4、intheoldergroups.The3-week-oldgroupwasdividedintotwopopulations.Themajorpopulationhadlowvirustitersanddevelopedpartialvillousatrophy,whereastheminorpopulationhadmarkedvillousatrophyandvirustiterscomparabletothoseofthenewbornpigs.Theseobserva-tionssupportthehypothesisthattheac
5、celeratedreplacementofvillousepitheliuminthesmallintestineofpigsduringthefirst3weekscontributestotheinnateage-dependentresistancetotransmissiblegastroenteritis.Theacceleratedreplacementofvillousepithelialcellsinolderpigscontributestoresistanceintwoways.Theincreasedproliferati
6、vecapac-ityofcryptepitheliumresultsinamorerapidregenerationofatrophicvilli;andthecom-parativelyyoungvillousabsorptivecellsresultingfromacceleratedreplacementproducelessviruspercellthantheolderonesofthenewbornpig.Transmissiblegastroenteritisofswineisanacutediarrhealdiseasecaus
7、edbydestructionofabsorptiveepithelialcellsoftheintestinalvillibyaspecificcoronavirus.Theresultantlesioniscalledvillousatrophy.Cryptepitheliumisnotaffecteddirectlybythevirus,andintestinalvillirapidlyregenerateinpigsthatsurvivetheacutediarrhealphaseofthedisease[16].Acuteviraldi
8、seasesofthesmallintestineinseveralspeciesfollowasimilarsequenceofsel
