LEEP治疗伴高危型HPV感染宫颈上皮内瘤变患者应用探析.doc

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1、LEEP治疗伴高危型HPV感染宫颈上皮内瘤变患者应用探析［摘要］目的探讨宫颈环形电切术（LEEP）治疗伴髙危型人乳头瘤病毒（HR—HPV）感染的宫颈上皮内瘤变（CIN）患者的应用价值。方法回顾性分析2009年1月〜2010年12月来我院妇科门诊经宫颈TCT诊断为ASCUS及以上的患者资料1280例，其中对HR—HPV感染、阴道镜下多点活检组织病理学确诊为宫颈上皮内瘤变的患者329例行LEEP治疗，对术前HR—HPV亚型、术后HR—HPV转阴及CIN预后情况进行分析。结果本组病例中HR—HPV阳性率52.19%,最常见的HR—HPV为16、58、52型。各HR—HPV阳性检出率

2、术后6个月和术后12个月分别下降为32.22%和10.33%,与术前比较差异具有统计学意义（x2=318.89,P<0.01）oLEEP手术治疗HR—HPV感染的总有效率达72.34%O结论LEEP治疗宫颈上皮内瘤变可以有效消除大部分HR—HPV感染，降低宫颈癌发生率。［关键词］LEEP；HR—HPV；CIN［中图分类号］R737.33［文献标识码］B［文章编号］1673—9701（2012）26—0146—03EfficacyanalysisoftheLEEPtreatmentincervicalintraepithelialneoplasiapatientswiththe

3、high——risktypehumanpapillomavirusinfectionFANSuhongYUXiaoXIALihuaDepartmentofGynecology，AffiliatedQuzhouCentralHospital,ZhejiangUniversityofTraditionalChineseMedicine,Quzhou324000,China[Abstract]ObjectiveTodiscusstheefficacyoftheloopelectrosurgicalexcisionprocedure(LEEP)treatmentincervicali

4、ntraepithelialneoplasia(CIN)patientswiththehigh一risktypehumanpapillomavirus(HR一HPV)infectiori.MethodsTheclinicaldataof1280casesofgynecologicclinicpatientsdiagnosedwithASCUSbycervicalTCTfromJanuary2009toDecember2010wereanalyzedretrospectively.Amongthem,329casesofpatientswithHR一HPVinfectionan

5、ddiagnosedwithCINbycolposcopicmulti一spotbiopsyhistopathologyunderwentroutineLEEPtreatment・ThepreoperativeHR一HPVsubtypes,postoperativenegativeturnandCINprognosiswereanalyzed・ResuItsThepositiverateinthisgroupwas52.19%，withHR一HPVtypes16，58，52beingthemostcommon.TheHR一HPVpositiveratewasreducedto

6、32.22%and10.33%respectivelyin6and12monthsafteroperation，showingstatisticalsignificancecomparedwiththepreoperativedata(x2=318.89,P<0.01).ThetotaleffectiverateofLEEPtreatmentinHR一HPVinfectionreached72.34%・ConclusionLEEPtreatmentofCINcaneffectivelyeliminatethemajorityofHR一HPVinfectionandreduce

7、theincideneeofcervicalcancer・[Keywords]Loopelectrosurgicalexcisionprocedure；High一risktypehumanpapillomavirus；Cervicalintraepithelialneoplasia宫颈癌是女性生殖系统最常见的恶性肿瘤[1],现有研究已证实高危型人乳头瘤病毒(HR—HPV)感染是引起女性宫颈上皮内瘤变(CIN)及宫颈癌的重要病因[2]。近年来，宫颈环形电切术(loopelectrosurgicalexci