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1、Tei指数评价原发性高血压患者左室功能障碍的临床研究【摘要】目的:探讨Tei指数原发性高血压患者心脏功能的临床应用价值。方法:原发性高血压患者176例,按Ganau分类法将原发性高血压分为4型:正常构型(A组,46例)、向心性重构(B组,53例)、向心性肥厚(C组,40例)、离心性肥厚(D组,37例);正常对照组35例。以常规超声心动图检杳测量舒张末期室间隔、左室后辟厚度及左室内径(IVS、LVPW、LVDed),二尖瓣Hll•流频谱图舒张早期与舒张晚期Hll.流峰值比(E/A),左室射血分数(EF)及Tei指数,进行对比分析。结果:1•一般资料的比
2、较:各组间年龄、性别差异均无显著性意义,C、D组病程有显著性差异,C、D组收缩压最高(Pv0.05),B、C、D组脉压最高(Pv0.05);2.各组超声心动图结构参数比较:C组、D组LA最大(PvO.05);B组LVDS最小(Pv0.05),D组LVDS最大(Pv0.05);C组IVS、LVPW最厚(Pv0.05);B组、D组IVS、LVPW轻度增厚(Pv0.05);C组RWT明显厚于其它各组(PvO.Ol);C组、D组LVMI质量显著增加(P<0.01),但C组、D组之间无统计学意义;3.各组超声心动图功能参数比较:高血压各纽•的E/A值均减低(P
3、vO.O5),EF只有D组与对照组比较有显著性意义;高血床各纽.Tei指数均较对照纽增加,呈递增趋势,各纽•间有显著性意义。结论:Tei指数町以客观、真实的评价高血压患者不同左室构型的心功能情况,对■于评估疾病的治疗效果和预后具有很高的临床应用价值。【关键词】原发性高血压;Tei指数;左室舒张功能;左室收缩功能ClinicalStudyontheLeftVentricularGlobalDysfunctioninPatientswithEssentialHypertensionwithTeiIndexYUANGuili,WANGYichengDepa
4、rtmentofCardiovascular,TheFirstAffiliatedHospital,HebeiNorthUniversity,Zhangjiakou,075000,Hebei,China【ABSTRACT]Objective:ToinvestigatetheclinicalapplicationofanewindexTeiindextormonitoringleftventricularglobalfunctioninpatientswithessentialhypertension.Methods:Inthisstudy」76pat
5、ientswithessentialhypertensionweredividedintofourgroups:normalleftventricle(groupA,46cases),concentricremodeling(groupB,53cases),concentrichypertrophy(groupC,40cases)eccentrichypertrophy(groupD,37cases),and35healthpersonsweretakenasthecontrolgroup.TheconventionalechoDoppleparam
6、etersassessedincluding:LA.LVDed.IVS.LVPW.LVMI.RWT,E/Aratio,ejectionfraction(EF)andTeiindex.Results:Comparedwiththatofthecontrolgroup,thesystolicpressureandpuslepressureingroupsC.Dwerehigher.LAwaslargeringroupsCD(P<0.05)IVS,RWTandLVPWingroupCwasthelargestinallgroups.LVMIingroups
7、C,Dwassignificantlylargestinallgroups(P<0.01),E/Ainallhypertensiongroupswasdecreased(P<0.05)TheEFwassignificantlyreducedingroupD(Pv0・05),Teiindexinallhypertentiongroupswasprolonged.Therewassignificantdifference(Pv0.05)・Conclusion:Teiindexwasvaluableandeasytoestimateleftventricu
8、larsystolicanddiastolicfunctionswithhighsensitivity.[K