片剂制备工业药剂.ppt

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1、PurposeIntroductionEquipmentsandMaterialsProceduresExperimentalInstructionsQuestionsTestreportPurpose1.Tomasterthebasictechnologicalcourseoftabletsthroughthepreparationofaspirintablets.2.Tobefamiliarwiththequalitycontroloftablets.3.Tobefamiliarwiththebasicstructureandoperationmethodofsingle-punch.In

2、troductionTabletsaresolidpreparationsofvariousshapes,usuallyround,andobtainedbycompressinguniformvolumesofparticlescontainingoneormoreactiveingredientswithsuitableexcipients.Introduction--tablettypesSomeofthepharmaceuticaltablettypesbasedonthewayofadministrationorpresentationtothepatientarelistedont

3、heright:1.Simpleuncoatedtablets2.Coatedtablets3.Effervescenttablets4.Buccalandsublingualtablets5.Chewabletablets6.Multilayeredtablets7.Sugarcoatedtablets8.Fast-disintegratingtablets9.Vaginaltablets10.Osmotictablets11.Controlled-releasetablets12.MulticomponenttabletsIntroduction--tabletdesignTabletfo

4、rmulationdesignstartswithapredeterminedvalue,whichisthedosesize.Tabletdesignisbasedontheexperienceandknowledgeofexcipients,whicharematerialsservingthepurposeofmakingagoodtabletwhencombinedwithadrug.Introduction--tabletdesignTabletexcipientscanbeclassifiedonthebasisoftheirfunctionalityaslistedbelow:1

5、.Fillers/diluents2.Binders3.Disintegrants4.Lubricants5.Glidants6.Bufferingagents7.Sweeteners8.Wettingagents9.Coatingagents10.MatrixformersIntroduction--manufacturingprocessesDecidingonamanufacturingmethodisacomplextaskthatrequirestime,equipment,andformulationoptimization,aswellasaclosecollaborationb

6、etweenformulationscientistsandprocessengineers.Ingeneralterms,therearethreemanufacturingprocessesfortablets:wetgranulation,drygranulation,anddirectcompression.Introduction--manufacturingprocessesThepurposeofwetgranulationistoconvertthedrugandexcipientmixtureintogranulesthatflowwellintodies,andwhicha

7、recompressibleintomechanicallystrongandacceptabletablets.1.flowability2.compressibilityWetgranulationcompressionmethodhasbeenwidelyusedintabletsproduction,especiallyfordrugsresistanttowetandheat.Intro