2、：earlylossoftransplantedislets→thelowefficiencyofislettransplantation●loss of transplanted islets iscaused by NKT cell–dependent IFN-γ production by Gr-1+CD11b+cells●in the activation of NKT cells and Gr-1+CD11b+cells in the early loss of transplanted islets remains
3、 to be solved.upstream eventsBackgroundHigh-mobility group box 1(HMGB1)protein: DNA-binding proteinpresent in almost all eukaryotic cells.HMGB1stabilizesnucleosomeformation and acts as a nuclear factor that enhances transcriptionHMGB1play crucial roles in response t
4、o tissue damage,issecreted by activated immune cells, including macrophages,DCs, and NKcellsHMGB1 inducesinflammatory responses by transduction of cellular signals through its receptors, such as TLR2, TLR4and receptor for advancedglycationend products (RAGE)Backgrou
6、ther withantibody once at the time of islettransplantationMethodsandResultsNonfastingplasmaglucoselevelsinSTZ-induceddiabeticmicereceivedisletstransplantationanddifferenttreatmentIFN-γproductionofNKTcellsandGr-1+CD11b+cellsintheliverreceivingisletsisinhibitedbyanti-
